Polymorphisms in Th17-related genes and the pathogenesis of autoimmune thyroid disease
Polymorphisms in Th17-related genes and the pathogenesis of autoimmune thyroid disease
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DOI：
10.1080/08916934.2018.1534963
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发表时间：
2018-01-01
期刊：
影响因子：
3.5
通讯作者：
Iwatani, Yoshinori
中科院分区：
文献类型：
--
作者：
Kunisato, Takayuki;Watanabe, Mikio;Iwatani, Yoshinori
自身免疫性甲状腺疾病（AITD）包括Graves病（GD）和桥本氏病（HD）的预后难以预测。我们以前认为Th17细胞可能与AITD的发病机制有关。然而，Th17相关基因的基因多态性与AITD预后之间的关系尚不清楚。为了阐明这种关联，我们对11个Th17相关基因的12个多态性进行了基因分型142例HD患者（包括58例重度HD患者和48例轻度HD患者）中的IL1Ra、IL6R、IL17R、IL21R、IL23R、CCR6、SOCS3、RORC、IL17A、IL17F和IL21，170例GD患者，包括81例难治性GD患者和49例缓解期GD患者，以及84例健康志愿者。IL17F rs763780 T等位基因在重度HD患者中的频率高于轻度HD患者（p= 0.008）。HD患者中IL17R rs9606615 T等位基因的频率高于正常受试者（p= 0.011）。难治性GD患者中SOCS3 rs4969170 AA基因型、CCR6 rs3093024 AA基因型和IL21 rs907715 AA基因型的频率高于缓解期GD患者（分别为p=.035、p=.002和p=.030）。总之，IL17R rs9607715和IL17F rs763780多态性分别与HD的易感性和严重程度相关。IL 21 rs907715、SOCS 3 rs4969170和CCR6 rs3093024多态性与难治性GD相关。
The prognosis of autoimmune thyroid disease (AITD) including Graves' disease (GD) and Hashimoto's disease (HD) is difficult to predict. We previously suggested that Th17 cells may be associated with the pathogenesis of AITD. However, the association between gene polymorphisms in Th17-related genes and the prognosis of AITD was not clarified. To clarify this association, we genotyped 12 polymorphisms in 11 Th17-related genes (IL1Ra, IL6R, IL17R, IL21R, IL23R, CCR6, SOCS3, RORC, IL17A, IL17F and IL21) in 142HD patients including 58 patients with severe HD and 48 patients with mild HD, 170 patients with GD including 81 patients with intractable GD and 49 patients with GD in remission, and 84 healthy volunteers. The frequency of the IL17F rs763780 T allele was higher in patients with severe HD than in patients with mild HD (p=.008). The frequency of the IL17R rs9606615 T allele was higher in patients with HD than in normal subjects (p=.011). The frequencies of the SOCS3 rs4969170 AA genotype, CCR6 rs3093024 AA genotype, and IL21 rs907715 AA genotype were higher in patients with intractable GD than in patients with GD in remission (p=.035, p=.002 and p=.030, respectively). In conclusion, IL17R rs9607715 and IL17F rs763780 polymorphisms are associated with the susceptibility and severity of HD, respectively. IL21 rs907715, SOCS3 rs4969170 and CCR6 rs3093024 polymorphisms are associated with the intractability of GD.