Lung tumors in 2 year old strain A/J mice exposed for 6 months to tobacco smoke.
Lung tumors in 2 year old strain A/J mice exposed for 6 months to tobacco smoke.
复制标题
暴露于烟草烟雾 6 个月的 2 岁 A/J 品系小鼠的肺部肿瘤。
DOI：
10.1016/j.canlet.2005.10.002
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发表时间：
2006
期刊：
影响因子：
9.7
通讯作者：
Maronpot,RobertR
中科院分区：
文献类型：
--
作者：
Witschi,Hanspeter;Espiritu,Imelda;Maronpot,RobertR
在全身吸入室中，将年轻成年A/J品系小鼠暴露于由肯塔基州1 R4 F研究香烟产生的89%侧流和11%主流香烟烟雾的混合物中6个月。烟雾成分的总悬浮颗粒物（TSP）的室浓度为158 mg/m3。在空气中再呆4个月后，一些动物被杀死。烟雾暴露动物的肺肿瘤多重性为1.8±0.2，对照组为0.9±0.2。在饲养超过12月龄的动物中，两组中的肺肿瘤多样性均增加，但与对照组相比，暴露于烟雾的动物中的肺肿瘤多样性始终保持为对照值的两倍（24月龄动物中每个肺4.3±0.7个肿瘤对2.1±0.5个肿瘤）。组织学显示，在2岁的动物中，仍有约80%的肿瘤是良性的。鼻腔内未见肿瘤。得出的结论是，烟草烟雾暴露不仅加速了最终自发发展的病变的发展，而且诱导了A/J小鼠肺肿瘤的从头形成。
Young adult strain A/J mice were exposed for 6 months in a whole-body inhalation chamber to a mixture of 89% sidestream and 11% mainstream cigarette smoke generated from Kentucky 1R4F research cigarettes. Chamber concentrations of smoke constituents were 158mg/m3of total suspended particulate matter (TSP). After an additional 4 months in air, some of the animals were killed. Lung tumor multiplicities in the smoke exposed animals were 1.8±0.2 versus 0.9±0.2 in controls. In animals kept beyond the age of 12 months, lung tumor multiplicities increased in both groups, but remained at all times twice the control values in the smoke exposed animals compared to controls (4.3±0.7 vs. 2.1±0.5 tumors per lung in 24 months old animals). Histopathology showed that, in 2 year old animals, still about 80% of tumors were of benign nature. No tumors were found in the nasal passages. It was concluded that tobacco smoke exposure not simply accelerates the development of lesions that eventually would have developed spontaneously, but induced de novo formation of lung tumors in A/J mice.