Correlation of stress and strain profiles and the distribution of osteoclastic cells induced by orthodontic loading in rat
Correlation of stress and strain profiles and the distribution of osteoclastic cells induced by orthodontic loading in rat
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DOI：
10.1111/j.1600-0722.2004.00116.x
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发表时间：
2004-04-01
影响因子：
1.9
通讯作者：
Jäger, A
中科院分区：
文献类型：
--
作者：
Kawarizadeh, A;Bourauel, C;Jäger, A
本研究的目的是调查是否应力或应变牙周膜（PDL），或者更确切地说，在骨，起着启动生物反应的正畸牙齿移动的作用。用镍钛合金螺旋弹簧近中移动11只Wistar大鼠的上颌第一磨牙3-12 d，并设3只大鼠为对照。石蜡组织学的上颌骨制备后，抗酒石酸酸性磷酸酶（TRAP）的活性进行了评价，以检测破骨细胞及其单核细胞前体在四个区域周围的近中根。基于组织切片，建立有限元模型。在牙槽骨和PDL中测定与正畸载荷相关的应力/应变分布，并与破骨细胞分布进行比较。在PDL中，正常的应力和应变是压缩（负）的破骨细胞的数量是最高的区域，而积极的正常拉伸应力和应变与破骨细胞的数量少的区域相一致。结果表明，在PDL中的计算的应力/应变值与破骨细胞在牙槽骨和PDL中的分布直接相关。因此，这些似乎是组织反应正畸力的应用，而骨的机械负荷似乎没有发挥作用，在正畸骨重建的主要机械因素。
The aim of this study was to investigate whether stress or strain within the periodontal ligament (PDL), or rather in the bone, plays a role in initiating biological responses in orthodontic tooth movement. The upper first molars of 11 Wistar rats were moved mesially with a closed nickel titanium alloy coil spring for 3-12 d and three rats served as controls. After preparation of the maxillae for paraffin histology, tartrate-resistant acid phosphatase (TRAP) activity was evaluated to detect osteoclasts and their mononuclear precursors in four regions around the mesial root. Based on histological sections, finite element models were developed. The stress/strain distributions associated with the orthodontic loading were determined in the alveolar bone and in the PDL and compared with the osteoclast distributions. In the PDL, the normal stresses and strains were compressive (negative) in regions where the number of osteoclasts was highest, whereas the positive normal tensile stresses and strains were coincident with regions with small numbers of osteoclasts. The results indicate a direct correlation of the calculated stress/strain values in the PDL with the distributions of osteoclasts in the alveolar bone and PDL. Thus, these seem to be the dominant mechanical factor of tissue reaction to orthodontic force application, whereas the mechanical loading of the bone does not seem to play a role in orthodontic bone remodeling.