Decreased apolipoprotein A5 is implicated in insulin resistance-related hypertriglyceridemia in obesity
Decreased apolipoprotein A5 is implicated in insulin resistance-related hypertriglyceridemia in obesity
复制标题
载脂蛋白 A5 减少与肥胖症中胰岛素抵抗相关的高甘油三酯血症有关
DOI：
10.1016/j.atherosclerosis.2009.12.004
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发表时间：
2010-06-01
期刊：
影响因子：
5.3
通讯作者：
Zhao, Wang
中科院分区：
文献类型：
--
作者：
Huang, Xian-sheng;Zhao, Shui-Ping;Zhao, Wang
肥胖者的高脂血症与胰岛素抵抗有关。载脂蛋白A5（apoA 5）参与甘油三酯（TG）代谢。本研究旨在探讨载脂蛋白A5在肥胖患者胰岛素抵抗相关高脂血症中的作用。本研究共招募了682名受试者，包括340名非肥胖者和342名肥胖者。测定血浆apoA 5水平。采用胰岛素抵抗稳态模型（HOMA-IR）评价胰岛素抵抗。以肥胖Zucker大鼠为阳性对照，采用高果糖饮食建立胰岛素抵抗和高胰岛素血症大鼠模型。此外，在体外用胰岛素和肿瘤坏死因子-α（TNF-α）诱导HepG 2细胞产生两种胰岛素抵抗模型。肥胖的参与者血浆apoA 5水平较低。人血浆apoA 5水平与TG、体重指数和HOMA-IR呈负相关。此外，果糖喂养大鼠的肝脏和血浆apoA 5减少，而肥胖Zucker大鼠中未观察到apoA 5的显著变化。此外，用胰岛素和TNF α处理HepG 2细胞降低apoA 5表达并增加TG含量。因此，载脂蛋白A5的减少与肥胖症的胰岛素抵抗相关的高脂血症有关。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Hypertriglyceridemia is associated insulin resistance in obese people. Recently identified apolipoprotein A5 (apoA5) is involved in triglyceride (TG) metabolism. This study was to investigate the role of apoA5 in insulin resistance-related hypertriglyceridemia in obesity. 682 participants including 340 non-obese individuals and 342 obese individuals were recruited in this study. Plasma apoA5 levels were measured. The insulin resistance in participants was assessed by homeostasis model assessment of insulin resistance (HOMA-IR). An insulin resistant and hypertriglyceridemic rat model was established by high-fructose diet with obese Zucker rats as positive controls. Besides, two insulin resistant models in vitro were induced by insulin and tumor necrosis factor-alpha (TNF alpha) in HepG2 cells. Obese participants had lower plasma apoA5 levels. Plasma apoA5 levels were inversely correlated with TG, body mass index and HOMA-IR in humans. Furthermore, hepatic and plasma apoA5 reduced in fructose-fed rats whereas no significant changes of apoA5 were observed in obese Zucker rats. In addition, treatment of HepG2 cells with insulin and TNF alpha decreased apoA5 expression and increased TG content. Thus, decreased apolipoprotein A5 is implicated in insulin resistance-related hypertriglyceridemia in obesity. (C) 2010 Elsevier Ireland Ltd. All rights reserved.