Functionalized nano-magnetic particles for an in vivo delivery system
Functionalized nano-magnetic particles for an in vivo delivery system
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DOI：
10.1166/jnn.2007.216
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发表时间：
2007-03-01
影响因子：
--
通讯作者：
Setou, Mitsutoshi
中科院分区：
文献类型：
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作者：
Moritake, Shinji;Taira, Shu;Setou, Mitsutoshi
纳米技术允许在体内无破坏性地引入载体，在治疗递送系统中具有广泛的潜力。我们用3-氨丙基三乙氧基硅烷进行硅烷化反应，制备了粒径为3 nm的功能性纳米磁性粒子。目的是用氨基官能化纳米颗粒的表面，以便随后与药物和生物分子交联。这些极小的颗粒被成功引入活细胞，无需任何进一步修饰即可增强内吞内化，例如使用阳离子辅助剂。含有内化颗粒的细胞继续茁壮成长，表明颗粒对有丝分裂没有抑制作用。此外，颗粒可以从耳部皮肤掺入小鼠耳部的皮下组织中，并且能够在施加外部磁场时定位。功能化的纳米磁性颗粒有望成为一种新的药物递送工具。
Nanotechnologies to allow the nondisruptive introduction of carriers in vivo have wide potential for therapeutic delivery system. We have prepared functional nano-magnetic particles (d = 3 nm) by silanization with (3-aminopropyl) triethoxysilane. For the purpose of functionalizing the surface of the nanoparticles with amino groups for subsequent cross-linking with pharmaceuticals and biomolecules. The extremely small particles were successfully introduced into living cells without any further modification to enhance endocytic internalization, such as the use of a cationic help. The cells containing the internalized particles continued to thrive, indicating that the particles have no inhibition effect for mitosis. In addition, the particles could be incorporated into the subcutaneous tissue of mouse's ear from ear skin and were able to be localized upon application of an external magnetic field. The functionalized nano-magnetic particles are expected to be useful as a new delivery tool.