Regulatory B cells control dendritic cell functions.
Regulatory B cells control dendritic cell functions.
复制标题
DOI：
10.2217/imt.11.34
复制
发表时间：
2011-04
期刊：
影响因子：
2.8
通讯作者：
R. Lo‐Man
中科院分区：
文献类型：
--
作者：
R. Lo‐Man
产生IL-10的B细胞是一个新的调节细胞家族，在先天和适应性水平上控制免疫应答。在新生儿的情况下，我们描述了这种调节性B细胞（BCRs）抑制对佐剂和疫苗的免疫应答。长期以来，人们一直认为免疫系统的不成熟是造成这种现象的原因;然而，越来越多的证据表明，免疫调节而不是不成熟在起作用。我们证明先天性CD5（+）Bcl2通过在Toll样受体触发后产生大量IL-10来负性控制新生小鼠的先天性炎症和树突状细胞功能。这些免疫调节机制可以防止致命的炎症，控制自身免疫性疾病的发展，如实验性自身免疫性脑脊髓炎，并可以在慢性炎症状态，如癌症中诱发。
IL-10-producing B cells are a new family of regulatory cells that control the immune responses at the innate and adaptive levels. In the neonatal context, we described that such regulatory B cells (Bregs) dampened immune responses to adjuvants and vaccines. For a long time, it has been postulated that immune system immaturity was responsible for this phenomenon; however, increasing evidence indicates that immune regulation rather than immaturity is at work. We demonstrated that innate CD5(+) Bregs negatively control innate inflammation and dendritic cell functions in neonatal mice by producing high amounts of IL-10 following Toll-like receptor triggering. These immune regulatory mechanisms can protect from lethal inflammation, control the development of autoimmune diseases, such as experimental autoimmune encephalomyelitis, and could be evoked in chronic inflammatory states, such as in cancer.