RAPID REINFECTION BY GIARDIA-LAMBLIA AFTER TREATMENT IN A HYPERENDEMIC THIRD-WORLD COMMUNITY
RAPID REINFECTION BY GIARDIA-LAMBLIA AFTER TREATMENT IN A HYPERENDEMIC THIRD-WORLD COMMUNITY
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DOI：
10.1016/s0140-6736(88)91131-2
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发表时间：
1988-02-13
期刊：
影响因子：
168.9
通讯作者：
MARTINEZ, H
中科院分区：
文献类型：
--
作者：
GILMAN, RH;MIRANDA, E;MARTINEZ, H
在秘鲁利马的一个蓝氏贾第鞭毛虫高度流行的城郊棚户区，44名年龄在0-9个月和10岁之间的儿童用替硝唑有效地治疗了蓝氏贾第鞭毛虫。治疗后6个月每周检查粪便，以确定再感染率，再感染后继续检查粪便。98%的儿童在6个月内再次感染蓝氏贾第鞭毛虫，再次感染后，粪便排泄的寄生虫持续平均（SD）3.2（3.3）个月。儿童的平均粪便pH值和平均粪便脂肪指数不受贾第虫再感染的影响。在一个发展中国家，由于快速的再感染，在该病高度流行的情况下治疗所有无菌的蓝氏贾第鞭毛虫感染的价值值得怀疑。
In a peri-urban shanty town in Lima, Peru, that was hyperendemic for Giardia lamblia, 44 children aged between 0-9 months and 10 years were effectively treated for Giardia lamblia with tinidazole. Stools were examined weekly in the 6 months after treatment to determine the rate of reinfection, and after reinfection stools continued to be examined. 98% of the children became reinfected with Giardia lamblia within 6 months, and after reinfection stool excretion of the parasite lasted a mean (SD) of 3.2 (3.3) months. The children''s mean stool pH and their mean stool fat index was unaffected by Giardia lamblia reinfection. Treatment of all symptomless Giardia lamblia infections in a developing country hyperendemic for the disease is of questionable value because of rapid reinfection.