PHASIC CORONARY BLOOD-FLOW VELOCITY IN INTRAMURAL AND EPICARDIAL CORONARY-ARTERIES
PHASIC CORONARY BLOOD-FLOW VELOCITY IN INTRAMURAL AND EPICARDIAL CORONARY-ARTERIES
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DOI：
10.1161/01.res.50.6.775
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发表时间：
1982-01-01
影响因子：
20.1
通讯作者：
MARCUS, ML
中科院分区：
文献类型：
--
作者：
CHILIAN, WM;MARCUS, ML
有关冠状动脉血流时相的知识主要基于从心外膜冠状动脉获得的测量结果，心外膜冠状动脉在一定程度上起着电容的作用。如果存在，心外膜电容效应可能会掩盖心肌内时相灌注的动态性质。为了分析心外膜电容的这种影响，测量了开胸麻醉犬心外膜动脉(左前降支)和室壁内动脉(室间隔)的冠脉血流速度。在对照条件下，每心动周期舒张期冠脉总血流速度的百分比间隔动脉(92%)显著高于左前降支(+3.5%)(P<；0.05)。心外膜小动脉穿入心肌前的血流速度测量显示出与间隔动脉相似的相型。一般情况下，穿透冠状动脉的时相血流速度模式不同于大的心外膜动脉。在硝酸甘油、潘生丁或20 S阻断左冠状动脉主干后的血管扩张过程中，尽管左前降支的收缩中期血流速度增加了300-400%，但收缩中期血流速度的逆行成分仍在间隔动脉持续存在。室壁内动脉和心外膜大动脉之间的这些定性和定量血流速度的差异可以通过假设存在显着的冠脉电容器来最好地调和。
Knowledge concerning phasic coronary blood flow is based primarily on measurements obtained from epicardial coronary arteries, which, in part, function as capacitors. If present, epicardial capacitance effects could obscure the dynamic nature of phasic intramyocardial perfusion. To analyze this effect of epicardial capacitance, coronary blood flow velocity was measured in an epicardial artery (left anterior descending) and an intramural artery (septal) in open-chest, anesthetized dogs. During control conditions, the percentage of total coronary blood flow velocity occurring during diastole per cardiac cycle was signficantly greater (P < 0.05) in the septal artery (92%) than in the left anterior descending artery (+3.5%). Blood flow velocity measurements from small epicardial arteries just before they penetrated into the myocardium revealed a phasic pattern similar to that of the septal artery. The phasic blood velocity pattern in penetrating coronary arteries, in general, is different than that in large epicardial arteries. During vasodilation following nitroglycerin, dipyridamole, or a 20 s occlusion of the left main coronary artery, the retrograde component of mid-systolic blood velocity persisted in the septal artery, despite large increases (300-400%) in the mid-systolic antegrade component of blood flow velocity in the left anterior descending artery. These qualitative and quantitative differences in phasic blood flow velocity between intramural and large epicardial arteries are best reconciled by postulating the existence of a significant coronary capacitor.