Differential effects of antidepressant treatment on brain monoaminergic receptors.
Differential effects of antidepressant treatment on brain monoaminergic receptors.
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抗抑郁药治疗对大脑单胺能受体的不同影响。
DOI：
10.1016/0014-2999(80)90152-1
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发表时间：
1980
影响因子：
5
通讯作者：
S. Enna
中科院分区：
文献类型：
--
作者：
A. Maggi;D. U'prichard;S. Enna
长期（21天）给大鼠服用抗抑郁药会导致选定大脑区域的血清素和β-肾上腺素能受体结合减少，但胆碱能毒蕈碱受体结合不会减少，额叶皮层似乎对这种效应更敏感。尼索西汀和氟西汀分别是去甲肾上腺素和血清素摄取的有效且特异性抑制剂，在长期给药后不会引起受体结合变化，这表明对递质摄取的抑制本身不足以引起受体不敏感。体外实验表明，抗抑郁药是相对较弱的α2-受体阻断剂，但有些对α1-受体系统有效，这表明一些抗抑郁药的去甲肾上腺素释放效力可能不是通过突触前自身受体的阻断来介导的。
Chronic (21 days) antidepressant administration to rats results in a decrease in both serotonin and β-adrenergic but not cholinergic muscarinic, receptor binding in selected brain regions, with the frontal cortex appearing to be somewhat more sensitive to this effect. Neither nisoxetine nor fluoxetine, potent and specific inhibitors of norepinephrine and serotonin uptake respectively, caused receptor binding changes after chronic administration, suggesting that inhibition of transmitter uptake, in itself, in insufficient to cause receptor subsensitivity. In vitro experiments indicated that antidepressants are relatively weakα2-receptor blocking agents, but some are potent on theα1-receptor system indicating that the norepinephrine releasing potency of some antidepressants may not be mediated by blockade of presynaptic autoreceptors.