Associations between MRI-defined synovitis, bone marrow lesions and structural features and measures of pain and physical function in hand osteoarthritis
Associations between MRI-defined synovitis, bone marrow lesions and structural features and measures of pain and physical function in hand osteoarthritis
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DOI：
10.1136/annrheumdis-2011-200341
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发表时间：
2012-06-01
影响因子：
27.4
通讯作者：
Kvien, Tore K.
中科院分区：
文献类型：
--
作者：
Haugen, Ida Kristin;Boyesen, Pernille;Kvien, Tore K.
目的探讨手部骨关节炎（OA）的MRI表现与疼痛和身体功能指标之间的关系。方法85例患者（77名女性），平均年龄68.8（5.6）岁，行指间关节（优势手）MRI增强扫描和临床关节评估。一名研究者根据拟定的奥斯陆手部OA MRI评分读取MRIs中骨赘、关节间隙狭窄、侵蚀、骨磨损、囊肿、对线不良、滑膜炎、屈肌腱鞘炎、骨髓病变（BML）和韧带不连续的存在/严重程度。通过关节触诊（压痛是/否）、自我报告问卷（澳大利亚/加拿大（AUSCAN）手指数、手骨关节炎功能指数（FIHOA）、关节炎影响测量量表-2（AIMS-2）手/手指）和握力评估疼痛和身体功能。使用广义估计方程的逻辑回归来探讨MRI特征的存在与关节压痛之间的相关性，并使用线性回归来研究MRI异常负荷与患者报告的结局和握力（根据年龄和性别调整）之间的相关性。MRI表现与p
Objectives To explore associations between MRI features and measures of pain and physical function in hand osteoarthritis (OA).Methods Eighty-five patients (77 women) with mean (SD) age of 68.8 (5.6) years underwent contrast-enhanced MRI of the interphalangeal joints (dominant hand) and clinical joint assessment. One investigator read the MRIs for presence/severity of osteophytes, joint space narrowing, erosions, bone attrition, cysts, malalignment, synovitis, flexor tenosynovitis, bone marrow lesions (BMLs) and ligament discontinuity according to the proposed Oslo hand OA MRI score. Pain and physical function were assessed by joint palpation (tenderness yes/no), self-reported questionnaires (Australian/Canadian (AUSCAN) hand index, Functional Index of hand osteoarthritis (FIHOA), Arthritis Impact Measurement Scale-2 (AIMS-2) hand/finger) and grip strength. Logistic regression with generalised estimating equations was used to explore associations between the presence of MRI features and joint tenderness, and linear regression for associations between the burden of MRI abnormalities and patient-reported outcomes and grip strength (adjusted for age and sex). MRI features with p