Ferulic Acid-Loaded Shellac Microparticles Prepared Using Electrohydrodynamic Atomization
Ferulic Acid-Loaded Shellac Microparticles Prepared Using Electrohydrodynamic Atomization
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DOI：
10.4028/www.scientific.net/amr.675.326
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发表时间：
2013-03
期刊：
影响因子：
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通讯作者：
Deng‐Guang Yu;W. Qian;Xia Wang;Y. Li;W. Lu;Yong Zhang
中科院分区：
文献类型：
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作者：
Deng‐Guang Yu;W. Qian;Xia Wang;Y. Li;W. Lu;Yong Zhang
采用电流体雾化（EHDA）法制备阿魏酸负载紫胶微粒。SEM观察表明，随着虫胶和FA在乙醇中的浓度从20%增加到50% (w/v)，粒径从0.68±0.21 μm逐渐增大到2.75±0.64 μm。广角x射线衍射分析表明，FA在紫胶基体微粒中已完全转化为无定形。衰减全反射傅里叶变换红外分析表明，FA与紫胶分子之间存在氢键。体外溶出试验证实，所有的微粒能够提供一个良好的持续药物释放轮廓。释放时间与微颗粒直径有密切关系。所有微粒都通过典型的菲克扩散机制释放负载的FA。本研究提供了一种简单的方法来开发新的药物递送微颗粒，以提供持续的药物释放谱。
An Electrohydrodynamic atomization (EHDA) process was exploited to prepare ferulic acid (FA)-loaded shellac microparticles. SEM observations showed that all the particles were round and solid with their sizes gradually increased from 0.68 ± 0.21 to 2.75 ± 0.64 μm as the concentrations of shellac and FA in ethanol raised from 20% to 50% (w/v). Wide-angle X-ray diffraction analyses demonstrated that FA had been totally converted into an amorphous state in the shellac matrix microparticles. Attenuated total reflectance Fourier transform infrared analysis disclosed that the hydrogen bonding presented between FA and shellac molecules. In vitro dissolution tests verified that all the microparticles were able to provide a fine sustained drug release profile. The release time periods had a close relationship with the diameters of microparticles. All the microparticles released the loaded FA via a typical Fickian diffusion mechanism. The present study provides an easy way to develop novel drug delivery microparticles for providing sustained drug release profiles.