Fluid mechanics of arterial stenosis: Relationship to the development of mural thrombus
Fluid mechanics of arterial stenosis: Relationship to the development of mural thrombus
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DOI：
10.1007/bf02648048
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发表时间：
1997-03-01
影响因子：
3.8
通讯作者：
Dewanjee, MK
中科院分区：
文献类型：
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作者：
Bluestein, D;Niu, LJ;Dewanjee, MK
在这项研究中，我们分析了血流通过模型狭窄与雷诺数范围从300到3,600使用实验和数值方法。在喉部产生的射流是湍流，导致缓慢回流的轴对称区域。对于较高的雷诺数，该区域变得更加扰动，其长度减少。数值预测得到了数字粒子图像测速仪的证实，并用于描述与先前测量的犬血流中血小板沉积相关的流体动力学机制（R。T. Schoephoerster等人，动脉粥样硬化和血栓形成12：1806-1813，1993）。实际沉积到壁上取决于狭窄处沿着的壁面剪应力分布，在流动再循环和再附着区域增加。在层流和湍流条件下，根据不同剪切应力和拉伸应力的累积效应，以及血小板沿沿着单个血小板路径暴露于这些应力的持续时间，分析了血小板活化潜力。剪切速率和沿血小板路径沿着暴露时间的累积乘积达到500的值，为恒定剪切下血小板活化所需值的一半（J.M. Ramstack等人，Journal of Biomechanics 12：113-125，1979）。
In this study, we analyzed blood flow through a model stenosis with Reynolds numbers ranging from 300 to 3,600 using both experimental and numerical methods. The jet produced at the throat was turbulent, leading to an axisymmetric region of slowly recirculating flow. For higher Reynolds numbers, this region became more disturbed and its length was reduced. The numerical predictions were confirmed by digital particle image velocimetry and used to describe the fluid dynamics mechanisms relevant to prior measurements of platelet deposition in canine blood flow (R. T. Schoephoerster et al., Atherosclerosis and Thrombosis 12:1806-1813, 1993). Actual deposition onto the wall was dependent on the wall shear stress distribution along the stenosis, increasing in areas of flow recirculation and reattachment. Platelet activation potential was analyzed under laminar and turbulent flow conditions in terms of the cumulative effect of the varying shear and elongational stresses, and the duration platelets are exposed to them along individual platelet paths. The cumulative product of shear rate and exposure time along a platelet path reached a value of 500, half the value needed for platelet activation under constant shear (J. M. Ramstack et al., Journal of Biomechanics 12: 113-125, 1979).