Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice
Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice
复制标题
细胞色素 P450 环氧化酶 CYP2J2 可减轻链脲佐菌素诱导的糖尿病小鼠的肾病。
DOI：
10.1016/j.prostaglandins.2011.06.009
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发表时间：
2011-11-01
影响因子：
2.9
通讯作者：
Wang, Dao Wen
中科院分区：
文献类型：
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作者：
Chen, Guangzhi;Wang, Peihua;Wang, Dao Wen
细胞色素P450 （CYP）环氧合酶将花生四烯酸代谢成环氧二十碳三烯酸（EETs）。它们在心血管系统中扮演着重要而多样的角色。eet在心血管系统中的抗炎、抗凋亡、促血管生成和抗高血压特性表明eet在糖尿病肾病中具有有益作用。本研究探讨了CYP2J2环氧合酶内皮特异性过表达对链脲佐菌素诱导的糖尿病小鼠糖尿病肾病的影响。通过尿微量白蛋白和肾小球硬化检测，内皮细胞CYP2J2过表达可减轻肾损害。这些作用与肾脏中tgf - β /Smad信号的抑制有关。事实上，CYP2J2的过表达阻止了tgf - β 1诱导的肾小管上皮-间质转化。这些发现强调了CYP环氧化酶- eet系统在糖尿病肾病发病机制中的有益作用。(C) 2011爱思唯尔公司版权所有。
Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs). which play important and diverse roles in the cardiovascular system. The anti-inflammatory, antiapoptotic, pro-angiogenic, and anti-hypertensive properties of EETs in the cardiovascular system suggest a beneficial role for EETs in diabetic nephropathy. This study investigated the effects of endothelial specific overexpression of CYP2J2 epoxygenase on diabetic nephropathy in streptozotocin-induced diabetic mice. Endothelial CYP2J2 overexpression attenuated renal damage as measured by urinary microalbumin and glomerulosclerosis. These effects were associated with inhibition of TGF-beta/Smad signaling in the kidney. Indeed, overexpression of CYP2J2 prevented TGF-beta 1-induced renal tubular epithelial-mesenchymal transition in vitro. These findings highlight the beneficial roles of the CYP epoxygenase-EET system in the pathogenesis of diabetic nephropathy. (C) 2011 Elsevier Inc. All rights reserved.