An epidemiological study with risk analysis of liver diseases in the general population living in a methyl mercury polluted area.
An epidemiological study with risk analysis of liver diseases in the general population living in a methyl mercury polluted area.
复制标题
甲基汞污染地区普通人群肝病流行病学研究及风险分析。
DOI：
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发表时间：
1992
影响因子：
6.3
通讯作者：
Dr Futatsuka
中科院分区：
文献类型：
--
作者：
M. Futatsuka;T. Kitano;M. Nagano;T. Inaoka;Yoshiki Arimatsu;Tatsuro Ueno;J. Wakamiya;Kenjiro Miyamoto;Kumamoto;Japan M Futatsuka;Dr Futatsuka
研究目的--目的是确定肝病的实际患病率，并调查甲基汞污染地区人群中各种危险因素对肝病的影响。设计--该研究是一项基于人群的横断面大规模筛查调查。一项病例对照研究旨在评估各种危险因素对肝脏疾病的作用。研究地点--本研究仅限于水俣市以北10公里的一个农村小镇。受试者-1406人年龄在50至69岁（78.3%的总人口在该地区的年龄）进行了检查。测量和主要结果-肝脏疾病的测量是在血液学，物理和超声检查的基础上进行的。通过问卷调查和测量身高、体重（肥胖）和B型肝炎表面抗原（HBsAg）收集肝脏危险因素的数据。男性肝脏肿瘤的患病率为0.5%，男性肝硬化的患病率为0.5%，女性为0.1%，男性肝炎的患病率为5.4%，女性为1.0%。女性患者组中肥胖受试者的肝病危险因素频率显著较高，男性患者组中有饮酒习惯的受试者的频率显著较高。既往输血史的比值比最高（7.73），归因危险度很高（87.1%），其次为HBsAg（比值比3.04;归因危险度67.1%）。结论--在这个甲基汞污染地区，肝病的患病率并没有增加，这与基于标准死亡率的预期相反。该地区肝病的主要危险因素似乎是饮酒习惯和输血史。
STUDY OBJECTIVE--The aim was to determine the actual prevalence of liver disease and to investigate the contribution of various risk factors to liver disease among the population in a methyl mercury polluted area. DESIGN--The study was a population based cross sectional mass screening survey. A case-control study was designed to estimate the role of various risk factors for liver diseases. SETTING--The study was confined to a small rural town 10 km north of Minamata City. SUBJECTS--1406 persons aged 50 to 69 years were examined (78.3% of the total population of this age in the locality). MEASUREMENTS AND MAIN RESULTS--Measurements of liver disease were made on the basis of haematological, physical, and ultrasonographic examinations. Data on liver risk factors were collected by questionnaire, and by measurement of body height, weight (obesity), and hepatitis B surface antigen (HBsAg). The prevalence rate of liver tumour was 0.5% in males, liver cirrhosis was found in 0.5% of males and 0.1% of females, and hepatitis was seen in 5.4% of males and 1.0% of females. Frequency rates of risk factors for liver disease among subjects with obesity were significantly higher in the female patient group, and the frequency rate among subjects with alcoholic drinking habits was significantly higher in the male patient group. The odds ratio of past history of blood transfusion showed the highest value among other related factors (7.73) and the attributable risk for this was very high (87.1%); HBsAg was next in rank (odds ratio 3.04; attributable risk 67.1%). CONCLUSIONS--The prevalence of liver disease in this methyl mercury polluted area was not increased, contrary to what was expected based on the standard mortality ratios. The main risk factors for liver disease in this area appear to be alcoholic drinking habits and a history of blood transfusion.