Interventional Treatment for Cholangiocarcinoma.

Interventional Treatment for Cholangiocarcinoma.
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DOI:
10.3389/fonc.2021.671327
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发表时间:
2021
影响因子:
4.7
通讯作者:
Guo JH
Guo JH
中科院分区:
医学3区
文献类型:
--
作者:
Li H;Chen L;Zhu GY;Yao X;Dong R;Guo JH

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胆管癌是第二常见的原发性肝脏恶性肿瘤。最新的分类包括肝内胆管癌和肝外胆管癌,后者进一步分为肝门周围和远端胆管癌。虽然手术切除是CCA的首选治疗方法,但实际上只有不到一半的患者符合根治性手术切除的条件。介入治疗,如动脉内治疗、消融和近距离放射治疗(碘-125粒子植入),已成为不可切除CCA患者可接受的姑息治疗。对这些患者,介入治疗有助于局部控制,缓解症状,提高生活质量。在此,我们将以及时和专题的方式,回顾这些进展,并在本文中强调未来的研究方向。
Cholangiocarcinoma (CCA) is the second most common type of primary liver malignancy. The latest classification includes intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma, with the latter one further categorized into perihilar and distal cholangiocarcinoma. Although surgical resection is the preferred treatment for CCA, less than half of the patients are actually eligible for radical surgical resection. Interventional treatment, such as intra-arterial therapies, ablation, and brachytherapy (iodine-125 seed implantation), has become an acceptable palliative treatment for patients with unresectable CCA. For these patients, interventional treatment is helpful for locoregional control, symptom relief, and improving quality of life. Herein, in a timely and topical manner, we will review these advances and highlight future directions of research in this article.
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