Sclerosing odontogenic carcinoma in the maxilla: a rare primary intraosseous carcinoma
Sclerosing odontogenic carcinoma in the maxilla: a rare primary intraosseous carcinoma
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DOI：
10.1016/j.oooo.2013.01.018
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发表时间：
2013-10-01
影响因子：
2.9
通讯作者：
Speight, Paul M.
中科院分区：
文献类型：
--
作者：
Hussain, Omar;Rendon, Alica Torres;Speight, Paul M.
硬化性牙源性癌最早是由Koutlas等人描述的。在2008年。SOC是一种低级别的牙源性癌，表现为扩张性的放射透明，导致牙齿移位和牙根吸收。它是局部侵袭性的，但报告显示区域或远处转移的可能性非常低。SOC由胞质透明的小立方或多边形上皮细胞组成的小巢和细索。多形性和有丝分裂不明显。伴有间质硬化症的骨骼肌和神经周围神经浸润症是其特征。免疫组织化学：细胞角蛋白(CK)5/6、19和E-钙粘素(E-Cad)染色。P63核染色也呈阳性。CK20、癌胚抗原和CAM5.2均为阴性。我们报道一例罕见的具有SOC临床和组织学标志的上颌骨原发骨内癌。发生在上颌骨的病例在以前的文献中只报道过一次。
Sclerosing Odontogenic Carcinoma (SOC) was first described by Koutlas et al. in 2008. SOC is a low-grade odontogenic carcinoma, which presents as an expansile radiolucency that causes tooth displacement and root resorption. It is locally aggressive but reports suggest a very low probability of regional or distant metastasis. SOC contains small nests and thin cords of small cuboidal or polygonal epithelial cells with cytoplasmic clearing. Pleomorphism and mitoses are not prominent. Skeletal muscle and perineural infiltration with stromal sclerosis is characteristic. Immunohistochemically, SOC stains for cytokeratins (CK) 5/6 and 19, and e-cadherin. Nuclear staining with p63 is also positive. CK20, carcinoembryonic antigen and CAM 5.2 are negative.We report a rare entity of primary intraosseous carcinoma of the maxilla which has the clinical and histological markers of SOC. Occurrence in the maxilla has been reported only once before in the literature.