South African GB virus C isolates: interactions between genotypes 1 and 5 isolates and HIV.
South African GB virus C isolates: interactions between genotypes 1 and 5 isolates and HIV.
复制标题
南非 GB 病毒 C 分离株：基因型 1 和 5 分离株与 HIV 之间的相互作用。
DOI：
10.1086/498170
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Stapleton,JackT
中科院分区：
文献类型：
--
作者：
Xiang,Jinhua;Sathar,MAslam;McLinden,JamesH;Klinzman,Donna;Chang,Qing;Stapleton,JackT
GB virus C (GBV-C) is a common, apparently nonpathogenic human flavivirus that has been associated in some studies with prolonged survival in human immunodeficiency virus (HIV)–positive persons. There are 5 distinct GBV-C genotypes localized to specific geographic regions, and genotype 2 has been previously shown to inhibit HIV replication in vitro in lymphocyte cultures. We identified GBV-C virus isolates representing genotypes 1, 2, and 5 in samples from South African blood donors. GBV-C genotype 1 and 5 isolates replicated in lymphocyte culture, inhibited X4 and R5 HIV-1 isolates, and induced RANTES and stromal-derived factor–1 chemokines in vitro. Thus, African GBV-C genotypes can inhibit HIV replication in vitro
