Thorax Injury Lowers Resistance to Infection in Drosophila melanogaster
Thorax Injury Lowers Resistance to Infection in Drosophila melanogaster
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DOI：
10.1128/iai.02415-14
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发表时间：
2014-10-01
影响因子：
3.1
通讯作者：
Lazzaro, Brian P.
中科院分区：
文献类型：
--
作者：
Chambers, Moria C.;Jacobson, Eliana;Lazzaro, Brian P.
感染途径可以深刻影响疾病的进展和结果。我们研究了果蝇防御细菌接种到两个网站后感染的差异-腹部和胸部。胸部接种导致细菌增殖增加，并在感染的最初几天内导致高死亡率。相比之下，腹部接种导致最小的死亡率和较低的细菌负荷比胸部接种。接种到任何一个部位都会引起全身感染。死亡率和细菌负荷的差异是由于胸部的损伤，并且可以通过腹部接种加上胸部的无菌创伤来概括。这种改变的抵抗力似乎独立于经典的免疫途径，并开辟了新的途径，研究损伤在防御感染过程中的作用。
The route of infection can profoundly affect both the progression and outcome of disease. We investigated differences in Drosophila melanogaster defense against infection after bacterial inoculation into two sites-the abdomen and the thorax. Thorax inoculation results in increased bacterial proliferation and causes high mortality within the first few days of infection. In contrast, abdomen inoculation results in minimal mortality and lower bacterial loads than thorax inoculation. Inoculation into either site causes systemic infection. Differences in mortality and bacterial load are due to injury of the thorax and can be recapitulated by abdominal inoculation coupled with aseptic wounding of the thorax. This altered resistance appears to be independent of classical immune pathways and opens new avenues of research on the role of injury during defense against infection.