THE EFFECT OF SHORT-TERM TOTAL PARENTERAL-NUTRITION ON HEPATIC-FUNCTION IN THE HUMAN NEONATE - A PROSPECTIVE RANDOMIZED STUDY DEMONSTRATING ALTERATION OF HEPATIC CANALICULAR FUNCTION
THE EFFECT OF SHORT-TERM TOTAL PARENTERAL-NUTRITION ON HEPATIC-FUNCTION IN THE HUMAN NEONATE - A PROSPECTIVE RANDOMIZED STUDY DEMONSTRATING ALTERATION OF HEPATIC CANALICULAR FUNCTION
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DOI：
10.1016/s0022-3476(81)80346-0
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发表时间：
1981-01-01
影响因子：
5.1
通讯作者：
KORONES, SD
中科院分区：
文献类型：
--
作者：
BLACK, DD;SUTTLE, EA;KORONES, SD
21名因呼吸道疾病而需接受全肠外营养(TPN)的婴儿随机分为试验组(TPN)和对照组(葡萄糖-电解质)。分别于入院时和治疗1wk时测定血清谷草转氨酶(SGOT)、谷丙转氨酶(SGPT)、γ-谷氨酰转氨酶(GGTP)、5‘’核苷酸酶、(5‘’-N)总、直接和结合型(邻氨基苯甲酸乙酯-反应性[EA]胆红素)和血清胆盐(SBS)浓度。TPN治疗1周后GGTP、5‘-N和EA胆红素显著升高，SGOT、SGPT、SBS、总胆红素和直接胆红素无明显变化。在TPN中加入脂质输注并不能改变这些差异。这些数据被解释为表明：氨基酸输注对肝功能有早期影响，这与使用这种疗法的许多疾病和同时使用脂类无关；最初的影响似乎是在小管膜上；而1wk的TPN显然不影响肝窦膜。
Twenty-one infants who were candidates for TPN [total parenteral nutrition) because of respiratory disease were randomized into experimental (TPN) and control (glucose-electrolyte) groups. Serum glutamic oxaloacetic transaminase (SGOT) serum glutamic pyruvic transaminase (SGPT), .gamma.-glutamyl transpeptidase (GGTP), 5'' nucleotidase, (5''-N) total, direct and conjugated (ethyl anthranilate-reactive [EA] bilirubin, and serum bile salt (SBS) concentrations were determined at entry into the study and at 1 wk. One week of TPN caused significant elevations of GGTP, 5''-N and EA bilirubin values; SGOT, SGPT, SBS and total and direct bilirubin were unaffected. Addition of a lipid infusion to TPN did not alter these differences. These data are interpreted as showing: amino acid infusion has an early effect on hepatic function which is independent of the many diseases for which this therapy is used and of the concomitant use of lipid; the initial effect appears to be on the canalicular membrane; and the sinusoidal membrane is apparently unaffected by 1 wk of TPN.