THE ABSORPTION OF ANTIBODY FROM IMMUNE SERA AND FROM MIXTURES OF SERA BY THE GUT OF THE YOUNG RAT
THE ABSORPTION OF ANTIBODY FROM IMMUNE SERA AND FROM MIXTURES OF SERA BY THE GUT OF THE YOUNG RAT
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DOI：
10.1098/rspb.1958.0008
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发表时间：
1958-01-01
期刊：
影响因子：
--
通讯作者：
HALLIDAY, R
中科院分区：
文献类型：
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作者：
HALLIDAY, R
从免疫大鼠血清经口单次给药至12日龄大鼠，传递至循环的抗体量与抗体浓度和给药剂量高达0.10 ml的血清体积成正比。传递的抗体量不随剂量增加而增加，并限于足以产生免疫血清的1/32的平均循环滴度。从单次饲料中摄取的含抗体球蛋白部分足以解释在至少9小时的时间内幼鼠血清蛋白中该部分的全部增加。从经口给予的免疫兔血清中传输到循环中的抗体比例随着剂量体积的增加而几乎线性下降，直至可给予的最大量为0-60 ml。从相应剂量的免疫血清至0.1ml，兔抗体的传递比例约为大鼠抗体的1/8。将某些异源血清与免疫大鼠或兔血清混合，经口给药，会干扰抗体向循环的传递，其程度无法通过稀释来解释。人、牛、豚鼠和兔血清具有显著作用，而绵羊、小鼠、仓鼠和大鼠血清几乎没有或没有作用。即使当混合血清的剂量体积小于0.10 ml时，也会干扰大鼠抗体的传播。虽然干扰降低了抗体传输到循环的比例，但它不会显着降低可以传输的最大量。
The amount of antibody transmitted to the circulation from immune rat serum administered by mouth in a single dose to 12-day-old rats is directly proportional both to the antibody concentration and to the volume of serum administered for doses up to 0.10 ml. The amount of antibody transmitted does not increase with larger doses and is limited to that sufficient to produce a mean circulating titre of 1/32 of that of the immune serum. The uptake of the antibody-containing globulin fraction from a single feed is sufficient to account for the whole of the increase in this fraction of the young rats'' serum protein over a period of at least 9 hr. The proportion of antibody transmitted to the circulation from immune rabbit serum administered by mouth declines nearly linearly with increasing volume of dose up to the maximum that could be administered of 0-60 ml. The proportion of rabbit antibody transmitted is approximately 1/8 of that of rat antibody from corresponding doses of immune serum up to 0.1 ml. Admixture of certain heterologous sera with the immume rat or rabbit serum administered by mouth interferes with the trans-mission of antibody to the circulation to an extent that cannot be accounted for by the dilution. Human, ox, guinea pig and rabbit sera have a marked effect, whereas sheep, mouse, hamster and rat sera have little or no effect. Interference with the transmission of rat antibodies results even when the volume of the dose of mixed sera is less than 0.10 ml. Although interference decreases the proportion of antibody transmitted to the circulation it does not reduce significantly the maximum amount that can be transmitted.