Expression patterns of β-catenin in in situ and invasive breast cancer
Expression patterns of β-catenin in in situ and invasive breast cancer
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DOI：
10.1053/ejso.1999.1017
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发表时间：
2001-02-01
期刊：
影响因子：
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通讯作者：
Pignatelli, M
中科院分区：
文献类型：
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作者：
Karayiannakis, AJ;Nakopoulou, L;Pignatelli, M
背景：β -Catenin在E-cadherin/catenin细胞-细胞粘附复合体中起核心作用，并可能参与细胞信号通路。在这项研究中，我们评估了该分子在原位和浸润性乳腺癌中的表达模式。方法：采用免疫组化方法检测121例乳腺癌标本中β -catenin的表达。并探讨了其与临床病理特征的关系。结果：β -catenin在68%的肿瘤中表达改变。小叶癌显示β -连环蛋白异常表达的频率（77%）高于导管癌（64%），其中46%的小叶癌病例显示完全没有β -连环蛋白免疫反应性。细胞质β -连环蛋白定位仅见于导管癌。-catenin在54%的导管原位癌中表达异常，且表达高度一致。β -catenin在附近原位和侵袭性组织中的表达模式。结论：β -catenin在原位癌和浸润性导管癌中有相当比例的定量和质变，在浸润性小叶癌中更为突出。(C) 2001哈考特出版有限公司
Background: beta -Catenin plays a central role in the E-cadherin/catenin cell-cell adhesion complex and is possibly involved in cellular signalling pathways. In this study, we evaluated the expression patterns of this molecule in in situ and invasive breast cancer.Methods: The expression of beta -catenin was evaluated in 121 breast cancer specimens by immunohistochemistry. Its relationship to clinicopathological features was also investigated.Results: Altered beta -catenin expression was found in 68% of tumours. Lobular carcinomas showed abnormal beta -catenin expression more frequently (77%) than ductal carcinomas (64%) with 46% of lobular cases showing complete absence of beta -catenin immunoreactivity. Cytoplasmic beta -catenin localization was seen only in ductal carcinomas. Aberrant beta -catenin expression was observed in 54% of ductal carcinomas in situ with highly concordant. beta -catenin expression patterns in the nearby in situ and invasive components.Conclusions: Quantitative and qualitative changes in beta -catenin expression occur in a considerable proportion of in situ and invasive ductal carcinomas and are more prominent in invasive lobular carcinomas. (C) 2001 Harcourt Publishers Ltd.