CORRELATED FIRING OF CAT RETINAL GANGLION-CELLS .1. SPONTANEOUSLY ACTIVE INPUTS TO X-CELL AND Y-CELL
CORRELATED FIRING OF CAT RETINAL GANGLION-CELLS .1. SPONTANEOUSLY ACTIVE INPUTS TO X-CELL AND Y-CELL
复制标题
DOI：
10.1152/jn.1983.49.2.303
复制
发表时间：
1983-01-01
影响因子：
2.5
通讯作者：
MASTRONARDE, DN
中科院分区：
文献类型：
--
作者：
MASTRONARDE, DN
通过研究相邻神经节细胞维持放电的相关性，研究了猫视网膜神经节细胞的共享输入。一个细胞的放电是从视束中的轴突记录的，而相邻细胞的放电是用视网膜中的第二个电极同时记录的。记录的细胞是X型或Y型的，并且观察到具有10 cd/m2亮度的均匀屏幕。具有重叠感受野中心的神经节细胞表现出两种基本形式的相关放电：如果它们具有相同的中心标志，（都在中心或都偏离中心），那么它们倾向于同时发射，如交叉相关图中的峰值所示;但如果它们具有相反的中心符号（中心上和偏离中心的单元），则它们倾向于不同时发射，如在它们的交叉相关图中的井或下降所示。这两种倾向都是最强的细胞是紧密相连的，并没有出现与非重叠的感受场中心的细胞。最强的相关性是相邻的Y-细胞，细胞与大的领域，和最弱的X-细胞，细胞与小的领域。一般来说，相关性的强度主要取决于场之间重叠的面积。维持放电的这些相关性似乎主要或完全是由来自更远侧视网膜神经元的对神经节细胞的共享输入引起的。来自这些远端神经元的信号似乎对神经节细胞具有强烈、短暂（4-8 ms）、明确的影响，即使在没有视觉刺激的情况下也能观察到。负责相关激发的输入被称为自发活动输入或简单地称为活动输入。对各种类型的交叉相关图中的特征的分析支持关于这些自发活动输入的陈述。有两种类型的主动输入：对中心细胞兴奋的输入，同时对偏离中心的细胞抑制，对偏离中心的细胞兴奋的输入，同时对中心细胞抑制。每种类型的主动输入都对一个中心符号的X细胞和Y细胞提供兴奋，对另一个中心符号的X细胞和Y细胞提供抑制。没有证据表明有一类特殊的更具选择性的输入只向X细胞或Y细胞提供输入。主动输入占大多数（约80%）的峰值，但仅一小部分（约80%）的峰值。15%）的峰值。主动输入信号的一个可能来源似乎是自发活动率低的无长突细胞。
The shared inputs to cat retinal ganglion cells were investigated by studying correlations in the maintained firing of neighboring ganglion cells. The firing of one cell was recorded from its axon in the optic tract, while that of a neighboring cell was simultaneously recorded with a 2nd electrode in the retina. The recorded cells were of the X- or Y-type and viewed a uniform screen having a luminance of 10 cd/m2. Ganglion cells with overlapping receptive-field centers showed 2 basic forms of correlated firing: if they had the same center sign (both on-center or both off-center), then they tended to fire at the same time, as shown by a peak in their cross-correlogram; but if they had opposite center signs (an on- and an off-center cell), they tended not to fire at the same time, as shown by a well, or dip, in their cross-correlogram. Both of these tendencies were strongest for cells that were close together and did not appear for cells with nonoverlapping receptive-field centers. The strongest correlations were between neighboring Y-cells, cells with large fields, and the weakest were between X-cells, cells with small fields. In general, the strength of the correlations depended primarily on the area of the overlap between fields. These correlations in maintained firing appear to be principally or entirely caused by shared inputs to the ganglion cells from more distal retinal neurons. The signals from these distal neurons appear to have strong, brief (4-8 ms), well-defined effects on ganglion cells, which are observed even in the absence of a visual stimulus. The inputs responsible for the correlated firing are referred to as spontaneously active inputs or simply as active inputs. An analysis of the features in the various types of cross-correlograms support statements about these spontaneously active inputs. There are 2 types of active inputs: inputs excitatory to on-center cells and simultaneously inhibitory to off-center cells and inputs excitatory to off-center cells and simultaneously inhibitory to on-center cells. The active inputs of each type provide excitation to both X- and Y-cells of one center sign and inhibition to both X- and Y-cells of the other center sign. There is no evidence for a special class of more selective inputs providing input only to X-cells or only to Y-cells. Active inputs account for the majority (.apprx. 80%) of the spikes in the maintained activity of Y-cells but only a small fraction (.apprx. 15%) of the spikes in the maintained activity of X-cells. A likely source of the active input signals appears to be spiking amacrine cells with a low rate of spontaneous activity.