Epidemiology of benign paroxysmal positional vertigo: a population based study
Epidemiology of benign paroxysmal positional vertigo: a population based study
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DOI：
10.1136/jnnp.2006.100420
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发表时间：
2007-07-01
影响因子：
11
通讯作者：
Neuhauser, H.
中科院分区：
文献类型：
--
作者：
von Brevern, M.;Radtke, A.;Neuhauser, H.
目的：研究一般人群中良性阵发性位置性眩晕（BPPV）的患病率和发病率、临床表现、社会影响和共病情况。方法：采用两阶段抽样设计，对德国一般成人人群进行横断面、全国代表性神经耳病学调查：对2003年德国全国电话健康访谈调查的4869名参与者进行筛查（应答率52%）中度或重度头晕或眩晕，其次是经过验证的神经耳病学访谈（n = 1003;应答率87%）。BPPV的诊断标准是至少5次前庭眩晕发作，持续1分钟，无伴随的神经系统症状，并且总是由头部位置的典型变化引起。在两个专门的头晕诊所进行的并行验证研究（n = 61），BPPV检测我们的电话采访的特异性为92%，敏感性为88%（阳性预测值88%，阴性预测值92%h.Results：BPPV占8%的个人中度或重度头晕/眩晕。BPPV的终生患病率为2.4%，1年患病率为1.6%，1年发病率为0.6%。一次发作的中位持续时间为2周。在86%受影响的人中，BPPV导致了医疗咨询，日常活动中断或病假。总体而言，只有8%的受影响参与者得到了有效的治疗。多因素分析显示，年龄、偏头痛、高血压、高血压和脑卒中与BPPV独立相关。结论：BPPV是一种常见的前庭疾病，导致显著的发病率、心理社会影响和医疗费用。
Objectives: To examine the prevalence and incidence, clinical presentation, societal impact and comorbid conditions of benign paroxysmal positional vertigo (BPPV) in the general population.Methods: Cross-sectional, nationally representative neurotological survey of the general adult population in Germany with a two stage sampling design: screening of 4869 participants from the German National Telephone Health Interview Survey 2003 (response rate 52%) for moderate or severe dizziness or vertigo, followed by validated neurotological interviews (n = 1003; response rate 87%). Diagnostic criteria for BPPV were at least five attacks of vestibular vertigo lasting,1 min without concomitant neurological symptoms and invariably provoked by typical changes in head position. In a concurrent validation study (n = 61) conducted in two specialised dizziness clinics, BPPV was detected by our telephone interview with a specificity of 92% and a sensitivity of 88% (positive predictive value 88%, negative predictive value 92%).Results: BPPV accounted for 8% of individuals with moderate or severe dizziness/vertigo. The lifetime prevalence of BPPV was 2.4%, the 1 year prevalence was 1.6% and the 1 year incidence was 0.6%. The median duration of an episode was 2 weeks. In 86% of affected individuals, BPPV led to medical consultation, interruption of daily activities or sick leave. In total, only 8% of affected participants received effective treatment. On multivariate analysis, age, migraine, hypertension, hyperlipidaemia and stroke were independently associated with BPPV.Conclusion: BPPV is a common vestibular disorder leading to significant morbidity, psychosocial impact and medical costs.