Npys-Mediated Elimination Reactions of Alcohols and Thiols: A Facile Route to Dehydroalanine and Dehydrobutyrine Building Blocks
Npys-Mediated Elimination Reactions of Alcohols and Thiols: A Facile Route to Dehydroalanine and Dehydrobutyrine Building Blocks
复制标题
Npys 介导的醇和硫醇消除反应：脱氢丙氨酸和脱氢丁酸结构单元的简便途径
作者：
Frank N. Olsen;Michail Tsakos;T. Poulsen
摘要我们报道了一种新的快速的丝氨酸、苏氨酸和半胱氨酸结构单元侧链脱水/脱氢硫醇化的方法。该方法依赖于用3-硝基-2-吡啶磺酰氯（Npys-Cl）活化，然后用碱处理。有可能以一锅法操作进行该序列，并且由于Npys-Cl的显著官能团相容性，该方法可与多官能和复杂底物相容。
Abstract We report a new and rapid method for side-chain dehydration/dehydrothiolation of serine, threonine, and cysteine building blocks. The method relies on activation with 3-nitro-2-pyridinesulfenyl chloride (Npys-Cl) followed by treatment with base. It is possible to perform the sequence as a one-pot operation and due to the significant functional-group compatibility of Npys-Cl, this method may be compatible with multifunctional and complex substrates.