New frontiers in molecular and imaging research on evaluation and diagnosis of bladder outlet obstruction in women.
New frontiers in molecular and imaging research on evaluation and diagnosis of bladder outlet obstruction in women.
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女性膀胱出口梗阻评估和诊断的分子和影像学研究新前沿。
DOI：
10.1007/s11884-017-0429-0
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发表时间：
2017
影响因子：
0.4
通讯作者：
Khavari,Rose
中科院分区：
文献类型：
--
作者：
Martinez,Laura;Khavari,Rose
综述的目的诊断膀胱出口梗阻（BOO）往往提出了一个挑战，在女性患者.传统的诊断要素，如症状史和尿动力学数据很少明确的妇女。因此，我们试图审查目前的文献女性BOO的诊断，专注于新的前沿领域的分子标记物和成像models.Recent FindingsIn除了荧光镜检查的设置videourodynamics，超声和MRI可以增强诊断和援助的治疗计划，在某些病因的女性BOO。此外，多种潜在的生物标志物（即，神经生长因子、肾上腺素、ATP），这些新技术可以增强女性BOO的标准临床和尿动力学评估。未来的方向包括进一步研究这些生物标志物中的每一个在女性BOO患者与正常对照相比，以测试其作为潜在的筛选工具的可行性。
Purpose of ReviewDiagnosis of bladder outlet obstruction (BOO) often presents a challenge in female patients. Traditional diagnostic elements such as symptom history and urodynamic data are rarely clear cut in women. Therefore, we sought to review the current literature on diagnosis of female BOO, focusing on new frontiers in the realm of molecular markers and imaging modalities.Recent FindingsIn addition to fluoroscopy in the setting of videourodynamics, ultrasound and MRI can augment the diagnosis and aid in therapeutic planning in certain etiologies of female BOO. Furthermore, multiple potential biomarkers (i.e., nerve growth factor, prostaglandins, ATP) that have been studied in correlation to BOO in animal models as well as human subjects hold promise for diagnostic applications.SummaryThese novel techniques may augment standard clinical and urodynamic evaluation of BOO in females. Future directions include further studies of each of these biomarkers in female patients with BOO compared to normal controls to test their feasibility as potential screening tools.