Death caused by recreational cocaine use.
Death caused by recreational cocaine use.
复制标题
因娱乐性使用可卡因而导致的死亡。
DOI：
--
复制
发表时间：
1979
期刊：
影响因子：
--
通讯作者：
R. Wright
中科院分区：
文献类型：
--
作者：
C. Wetli;R. Wright
佛罗里达州戴德县法医办公室调查了68起与娱乐使用非法可卡因有关的死亡事件。大多数死亡事件发生在1975年以来。尽管有29人涉及使用其他毒品(通常是海洛因)，但有24人直接死于可卡因的毒害作用。静脉注射可卡因后，呼吸衰竭和死亡迅速发生。口服或经鼻摄入导致持续长达一小时的无症状间歇，随后突然出现全身癫痫发作和死亡。毒理学分析不能将盐酸利多卡因或其他掺假物与不良反应联系起来。这些数据表明，吸收率、峰值血药浓度以及之前使用可卡因都会增加发生致命反应的可能性。尽管目前人们认为，可卡因不能被认为是一种安全的娱乐毒品。
Sixty-eight deaths associated with the recreational use of illicit cocaine were investigated by the Medical Examiner's Office of Dade County in Florida. Most fatalities occurred since 1975. Although 29 involved the use of other drugs (usually heroin), 24 persons died directly of the toxic effects of cocaine. Respiratory collapse and death occurred rapidly after the intravenous injection of cocaine. Oral or nasal ingestion resulted in a symptom-free interval lasting as long as an hour followed suddenly by generalized seizures and death. Toxicological analysis could not causally relate lidocaine hydrochloride or other adulterants to the untoward reactions. The data suggest that the rate of absorption, the peak blood concentration, and the prior use of cocaine all contribute to the possibility of a fatal reaction. Despite current belief, cocaine cannot be considered a safe recreational drug.