A precisely assembled carbon source to synthesize fluorescent carbon quantum dots for sensing probes and bioimaging agents (IF:5.16)
A precisely assembled carbon source to synthesize fluorescent carbon quantum dots for sensing probes and bioimaging agents (IF:5.16)
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精确组装的碳源，用于合成用于传感探针和生物成像剂的荧光碳量子点（IF：5.16）
DOI：
10.1002/chem.201705310
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Qiao YQ;Luo D;Yu M;Zhang T;Cao XP;Zhou YH;Liu Y
广泛的碳源已被用于制造各种碳量子点（CQDs）。然而，这些研究大多涉及前体的一级结构和化学成分对CQDs的影响；碳源的上层结构是否对合成CQDs的理化性质有影响尚不清楚。在这项工作中，首次将分子组装的概念引入到新碳源的设计中。与原胶原分子相比，分层组装的胶原支架作为一种新的碳源，通过氢键、静电吸引和疏水力固定前驱体的官能团。此外，胶原自组装中官能团的积累进一步促进了通过水热过程获得的CQDs中共价键的形成。这两种化学性质的优势都可以产生高质量的发光增强的cqd。杂原子掺杂合成的基于胶原支架的CQDs具有优异的稳定性，可进一步作为Fe3+检测和细胞质成像的有效荧光探针。这些发现为从具有组装上层结构的前体中探索更多纳米碳提供了丰富的可能性。
A broad range of carbon sources have been used to fabricate varieties of carbon quantum dots (CQDs). However, the majority of these studies concern the influence of primary structures and chemical compositions of precursors on the CQDs; it is still unclear whether or not the superstructures of carbon sources have effects on the physiochemical properties of the synthetic CQDs. In this work, the concept of molecular assembly is first introduced into the design of a new carbon source. Compared with the tropocollagen molecules, the hierarchically assembled collagen scaffolds, as a new carbon source, immobilize functional groups of the precursors through hydrogen bonds, electrostatic attraction, and hydrophobic forces. Moreover, the accumulation of functional groups in collagen self‐assembly further promotes the covalent bond formation in the obtained CQDs through a hydrothermal process. Both of these two chemical superiorities give rise to high quality CQDs with enhanced emission. The assembled collagen scaffold‐based CQDs with heteroatom doping exhibit superior stability, and could be further applied as effective fluorescent probes for Fe3+detection and cellular cytosol imaging. These findings open a wealth of possibilities to explore more nanocarbons from precursors with assembled superstructures.