Identifying early glaucomatous changes -: Comparison between expert clinical assessment of optic disc photographs and confocal scanning ophthalmoscopy
Identifying early glaucomatous changes -: Comparison between expert clinical assessment of optic disc photographs and confocal scanning ophthalmoscopy
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DOI：
10.1016/s0161-6420(00)00363-8
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发表时间：
2000-12-01
期刊：
影响因子：
13.7
通讯作者：
Hitchings, RA
中科院分区：
文献类型：
--
作者：
Wollstein, G;Garway-Heath, DF;Hitchings, RA
目的：比较专业临床医生利用立体视盘照片和激光眼底共聚焦扫描成像对正常人和早期青光眼患者的鉴别能力。设计：对比仪器验证研究。受试者：72名健康人和51例早期青光眼患者(平均视野平均偏差-3.6分贝)。在高级青光眼干预研究分类中，早期青光眼被定义为高眼压史和评分小于或等于5分的可重复性视野缺陷，与视盘外观无关。干预：立体视神经头(ONH)摄影和海德堡视网膜断层扫描仪(HRT)成像，(德国多森海姆海德堡工程股份有限公司)。临床评估立体ONH照片和分析HRT参数的主要结果衡量能力，考虑视盘大小，以检测早期青光眼视盘改变。结果：5位观察者多数意见诊断早期青光眼视盘改变的特异度为94.4%，敏感度为70.6%。HRT分析的特异度为95.8%，敏感度为84.3%。结论：考虑视盘大小的海德堡视网膜断层图像分析在鉴别健康人和早期青光眼患者方面比临床评价视盘立体像更敏感。(C)2000年由美国眼科学会授予。
Objective: To compare the ability of expert clinicians, using qualitative assessment of stereoscopic optic disc photographs, and confocal scanning laser ophthalmoscope imaging to discriminate between healthy persons and patients with early glaucoma.Design: Comparative instrument validation study.Participants: Seventy-two healthy persons and 51 patients with early glaucoma (average visual field mean deviation, -3.6 dB). Early glaucoma was defined as a history of ocular hypertension and a reproducible visual field defect scoring 5 or less in the Advanced Glaucoma Intervention Study classification, regardless of optic disc appearance.Intervention: Stereoscopic optic nerve head (ONH) photography and Heidelberg Retina Tomograph (HRT) imaging, (Heidelberg Engineering GmbH, Dossenheim, Germany).Main Outcome Measurer Ability of clinical assessment of stereoscopic ONH photographs and analysis of HRT parameters, taking into account the optic disc size, to detect early glaucomatous optic disc changes. Results: The specificity of the majority opinion of five observers to detect early glaucomatous optic disc changes was 94.4%, with a sensitivity of 70.6%. Using the HRT analysis, the specificity was 95.8% and the sensitivity was 84.3%.Conclusions: Heidelberg Retina Tomograph image analysis that takes into account the optic disc size is more sensitive than clinical assessment of stereoscopic optic disc photographs in distinguishing between healthy persons and patients with early glaucoma. (C) 2000 by the American Academy of Ophthalmology.