Changes in plasma and urinary taurine and amino acids in runners immediately and 24h after a marathon
Changes in plasma and urinary taurine and amino acids in runners immediately and 24h after a marathon
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DOI：
10.1007/s007260170062
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发表时间：
2001-01-01
期刊：
影响因子：
3.5
通讯作者：
de Witte, P
中科院分区：
文献类型：
--
作者：
Cuisinier, C;Ward, RJ;de Witte, P
对参加1998年鹿特丹马拉松比赛的训练有素的运动员在完成比赛后即刻和恢复后24小时尿液和血浆牛磺酸和氨基酸的变化进行了评估。尿氨基酸排泄量有显著变化，大多数在马拉松结束时和恢复24小时后都有显著下降。相比之下，马拉松结束后尿牛磺酸排泄量立即增加，尽管结果范围很广，但并不显著。尿牛磺酸的这种变化与赛后即刻(r=0.972，P<；0.001)和赛后24小时(r=0.872，P<；0.001)血浆肌酸激酶的百分比变化有关，可能表明牛磺酸的来源是肌肉。计算了所有运动员尿液和血浆氨基酸的显著相关性：牛磺酸(r=0.528)、甘氨酸(r=0.853)、苏氨酸(r=0.749)、丙氨酸(r=0.747)、丝氨酸(r=0.620)、谷氨酰胺(0.614)、精氨酸(r=0.507)、组氨酸(r=0.470)和缬氨酸(r=0.486)。1999年)，大多数人在马拉松比赛后立即和24小时出现显著下降，这种适应主要是由于它们被用于糖异生。然而，相比之下，平均牛磺酸浓度在比赛后，P<；0.01和24，P<；0.05都显著升高。肌肉对力竭运动的生理反应，特别是血浆和尿牛磺酸浓度的变化，仍有待阐明，但可能与肌肉功能损害有关。牛磺酸尿排泄量的增加可以作为力竭运动过程中肌肉损伤的一个指标。补充牛磺酸是否会将这种变化降至最低是一个有趣的科学问题，值得研究。
Changes in urinary and plasma taurine and amino acids have been evaluated in trained runners competing in the Rotterdam Marathon, 1998, both immediately after completing the event and 24h after recovery. There were significant changes in the urinary amino acids excretion, the majority showing a significant decrease both immediately at the completion of the Marathon and after 24h recovery. In contrast urinary taurine excretion increased immediately post Marathon, although not significantly as the range of results was wide. Such changes in urinary taurine correlated with percentage changes in plasma creatine kinase both immediately post race, (r = 0.972, P < 0.001), and 24h later (r = 0.872, P < 0.001), possibly indicating that the source of the taurine was muscle. Significant correlations between the individual values for urinary and plasma amino acids in all of the athletes were calculated for taurine (r = 0.528), glycine (r = 0.853), threonine (r = 0.749), alanine (r = 0.747), serine (r = 0.620), glutamine (0.614), arginine (r = 0.507), histidine (r = 0.470) and valine (r = 0.486).Changes in the mean plasma concentrations of amino acids were comparable to our previously published data (Ward et al., 1999) the majority showing significant decreases immediately and 24h post Marathon, such an adaptation being due primarily to their utilisation for gluconeogenesis. However, in contrast, the mean taurine concentrations were significantly elevated both post race, P < 0.01 and after 24h, P < 0.05.The physiological response by the muscle to exhaustive exercise, particularly with regard to changes in plasma and urinary taurine concentrations remain to be elucidated, but is probably related to muscle function impairment. The increase in taurine urinary excretion could be used as an indicator of muscle damage occurring during exhaustive exercise. Whether taurine supplementation would minimise such changes is an interesting scientific question and merits investigation.