Epidemiological transition of colorectal cancer in developing countries: Environmental factors, molecular pathways, and opportunities for prevention
Epidemiological transition of colorectal cancer in developing countries: Environmental factors, molecular pathways, and opportunities for prevention
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DOI：
10.3748/wjg.v20.i20.6055
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发表时间：
2014-05-28
影响因子：
4.3
通讯作者：
Mariani-Costantini, Renato
中科院分区：
文献类型：
--
作者：
Bishehsari, Faraz;Mahdavinia, Mahboobeh;Mariani-Costantini, Renato
结直肠癌(CRC)是世界范围内癌症和癌症相关死亡的主要原因之一。这种疾病传统上是工业国家的一个主要健康问题，但在正在经历经济增长的发展中国家，结直肠癌的发病率正在上升。一些环境风险因素，主要是饮食和生活方式的改变，被认为是这些人群中结直肠癌上升的基础。饮食和生活方式对核受体、肠道微生物区系和与肠道癌变有关的关键分子通路的影响。在这方面，世界几个地区的流行病学转变提供了一个独特的机会，通过研究疾病表型及其在不同人群中的环境和分子相关性，更好地了解结直肠癌的发生。这些研究的数据可能对全球预防和治疗结直肠癌具有重要意义。(C)2014百仕登出版集团有限公司，版权所有。
Colorectal cancer (CRC) is one of the leading causes of cancer and cancer-related mortality worldwide. The disease has been traditionally a major health problem in industrial countries, however the CRC rates are increasing in the developing countries that are undergoing economic growth. Several environmental risk factors, mainly changes in diet and life style, have been suggested to underlie the rise of CRC in these populations. Diet and lifestyle impinge on nuclear receptors, on the intestinal microbiota and on crucial molecular pathways that are implicated in intestinal carcinogenesis. In this respect, the epidemiological transition in several regions of the world offers a unique opportunity to better understand CRC carcinogenesis by studying the disease phenotypes and their environmental and molecular associations in different populations. The data from these studies may have important implications for the global prevention and treatment of CRC. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.