The strong relationship between bipolar and substance-use disorder Mechanisms and treatment implications
The strong relationship between bipolar and substance-use disorder Mechanisms and treatment implications
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DOI：
10.1111/j.1749-6632.2009.05146.x
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发表时间：
2010-01-01
期刊：
影响因子：
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通讯作者：
Swann, Alan C.
中科院分区：
文献类型：
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作者：
Swann, Alan C.
Bipolar disorder and substance-use disorders commonly occur in the same individual. In fact, bipolar disorder has a higher prevalence of substance-use disorders than any other psychiatric illness. Individuals with both disorders have a more severe course of bipolar disorder, including earlier onset, more frequent episodes, and more complications, including anxiety- and stress-related disorders, aggressive behavior, legal problems, and suicide. Bipolar and substance-use disorders share common mechanisms, including impulsivity, poor modulation of motivation and responses to rewarding stimuli, and susceptibility to behavioral sensitization. Studies of potential treatments for bipolar substance-use disorder have paid scant attention to the combined disorders. The most promising treatment strategies are those that address their shared mechanisms.
