Detection and characterization of neurotoxicity in cancer patients using proton MR spectroscopy.
Detection and characterization of neurotoxicity in cancer patients using proton MR spectroscopy.
复制标题
使用质子磁共振波谱法检测和表征癌症患者的神经毒性。
DOI：
10.1007/s00381-007-0576-2
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Warren,KatherineE
中科院分区：
文献类型：
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作者：
Steffen-Smith,EmilieA;Wolters,PamelaL;Albert,PaulS;Baker,EvaH;Shimoda,KimC;Barnett,AlanS;Warren,KatherineE
目的研究质子磁共振波谱成像（1H-MRSI）测定的脑代谢比率与神经毒性危险癌症患者神经心理（NP）功能之间的异常和关系。方法32例患者在1.5T磁铁上采用多层、多体素技术行1h - mrsi。Cho/NAA， NAA/Cr和Cho/Cr比值在7个预先确定的无肿瘤累及的部位被确定。在成像后7天内进行一系列适合年龄的NP测试。研究了测试分数与代谢物比率之间的关系。结论本研究确定了癌症患者脑代谢物比率与认知功能之间的关系。1H-MRSI可能有助于早期发现神经毒性作用，但建议在同质人群中进行前瞻性纵向研究以确定预后价值。
ObjectiveThe study objective was to detect abnormalities and identify relationships between brain metabolic ratios determined by proton magnetic resonance spectroscopic imaging (1H-MRSI) and neuropsychological (NP) function in cancer patients at risk for neurotoxicity.MethodsThirty-two patients received1H-MRSI using a multi-slice, multi-voxel technique on a 1.5T magnet. Cho/NAA, NAA/Cr, and Cho/Cr ratios were identified in seven pre-determined sites without tumor involvement. A battery of age-appropriate NP tests was administered within 7 days of imaging. Relationships were examined between test scores and metabolite ratios.ConclusionsThis study identifies relationships between brain metabolite ratios and cognitive functioning in cancer patients.1H-MRSI may be useful in early detection of neurotoxic effects, but prospective longitudinal studies in a homogeneous population are recommended to determine the prognostic value.