Peyer's patches: organizing B-cell responses at the intestinal frontier.
Peyer's patches: organizing B-cell responses at the intestinal frontier.
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DOI：
10.1111/imr.12400
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发表时间：
2016-05
影响因子：
8.7
通讯作者：
Cyster JG
中科院分区：
文献类型：
--
作者：
Reboldi A;Cyster JG
次级淋巴组织具有将抗原和稀有的抗原特异性淋巴细胞聚集在一起以促进适应性免疫反应的重要功能。与其他次级淋巴组织相比，Peyer‘s Patches(PP)在持续暴露于微生物和食物来源抗原的巨大多样性以及所遇到的病原体类型方面是独一无二的。抗原由特殊的微折叠(M)上皮细胞递送到PPS，它们可能被常驻树突状细胞(DC)捕获和呈递。与其长期接触微生物抗原的状态相一致，PPS表现出持续的生发中心(GC)活性。这些GC有助于B细胞和浆细胞的产生，产生体细胞突变的肠道抗原特异性IgA抗体，但也被认为支持B细胞系的非抗原特异性多样化。在这里，我们回顾了目前对PPS如何促进B细胞与抗原相遇，它们如何促进同型转换为分泌型IgA同型，以及它们的GC反应如何独特地促进粘膜免疫的理解。
Secondary lymphoid tissues share the important function of bringing together antigens and rare antigen-specific lymphocytes to foster induction of adaptive immune responses. Peyer’s patches (PPs) are unique compared to other secondary lymphoid tissues in their continual exposure to an enormous diversity of microbiome- and food-derived antigens and in the types of pathogens they encounter. Antigens are delivered to PPs by specialized microfold (M) epithelial cells and they may be captured and presented by resident dendritic cells (DCs). In accord with their state of chronic microbial antigen exposure, PPs exhibit continual germinal center (GC) activity. These GCs contribute to the generation of B cells and plasma cells producing somatically mutated gut antigen-specific IgA antibodies, but have also been suggested to support antigen-nonspecific diversification of the B cell repertoire. Here we review current understanding of how PPs foster B cell encounters with antigen, how they favor isotype switching to the secretory IgA isotype, and how their GC responses may uniquely contribute to mucosal immunity.