Risk factors for caries development in primary Sjogren syndrome
Risk factors for caries development in primary Sjogren syndrome
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DOI：
10.1016/j.oooo.2019.04.011
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发表时间：
2019-08-01
影响因子：
2.9
通讯作者：
Pinto, Andres
中科院分区：
文献类型：
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作者：
Berman, Nicola;Vivino, Frederick;Pinto, Andres
目标。这项研究的目的是比较原发性干燥综合征(SS)和非干燥综合征(NSS)唾液功能低下患者的龋病危险因素，并确定两组中切牙或颈部/根面龋齿的患病率。这是一项在2012至2015年间在单一中心进行的回顾性横断面研究，目的是评估可能患有SS的患者。225例患者(99例SS和126例NSS)参与研究。连续变量的组间差异采用t检验和Wilcoxon的秩和检验，类别变量的差异采用X~2检验。使用多变量有序回归模型进一步评估显著的单变量相关性。SS患者的总龋数更多(优势比[OR]1.72[1.03-2.88]；P=0.04)。病灶积分大于1/4 mm(2)与总龋数增加相关(OR 2.88[1.05，7.93]；P=0.04]。调整后的唾液流量分析未显示刺激或非刺激唾液流量或腺特异性唾液流量与龋损总数之间存在显著的相关性。继发于SS的唾液功能减退的患者与其他因素引起的唾液功能减退的患者相比，确实有更大的龋病风险。在这项研究队列中，这一发现与唾液流率无关。
Objectives. The aim of this study was to compare the risk factors for caries between patients with primary Sjogren syndrome (SS) and those with non-Sjogren syndrome (NSS) salivary hypofunction and to identify the prevalence of incisal or cervical/root caries in each group.Study Design. This was a retrospective, cross-sectional study conducted at a single center between 2012 and 2015 for assessment of patients with possible SS. Two-hundred and twenty-five (225) patients (99 SS and 126 NSS) participated in the study.Results. Student t test and Wilcoxon's rank sum test were used to evaluate group differences in continuous variables and the chi(2) test was used to determined differences in categorical variables. Significant univariate associations were further assessed by using multivariate ordinal regression models. Patients with SS were more likely to have a greater number of total caries (odds ratio [OR] 1.72 [1.03-2.88]; P = .04). And a focus score greater than 1/4 mm(2) was associated with greater number of total caries (OR 2.88 [1.05, 7.93]; P = .04]. Adjusted analysis for salivary flow did not show a significant association between stimulated or unstimulated salivary flow or glandular-specific salivary flow and the total number of carious lesions.Conclusions. Patients with salivary hypofunction secondary to SS do have a greater caries risk compared with patients with salivary hypofunction caused by other factors. In this study cohort, this finding was not associated with salivary flow rates.