Systematic Screening of the Chemical Constituents of Lanqin Oral Liquid by Ultra-High-Performance Liquid Chromatography Combined with Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.
Systematic Screening of the Chemical Constituents of Lanqin Oral Liquid by Ultra-High-Performance Liquid Chromatography Combined with Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.
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DOI：
10.3390/molecules28207053
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发表时间：
2023-10-12
期刊：
影响因子：
--
通讯作者：
Lin S
中科院分区：
文献类型：
--
作者：
Liu T;Lin S
采用超高效液相色谱结合傅立叶变换离子回旋共振质谱仪(UHPLC-FT-ICR-MS)快速、灵敏地鉴定兰芹口服液的化学成分。在UHPLC-FT-ICR-MS分析的基础上，对兰芹口服液的化学成分进行了系统的表征，共鉴定或初步鉴定了生物碱、黄酮类、萜类、有机酸类、苯丙类等441种化合物。研究结果为进一步完善兰芹口服液的质量控制提供了参考，有助于制定更高的质量标准，为进一步研究兰芹口服液的药效学物质基础提供了科学依据，有助于阐明兰芹口服液复杂的成分与疗效的关系。
A rapid and sensitive method that combined ultra-high-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry (UHPLC-FT-ICR-MS) was used to identify the chemical constituents in Lanqin oral liquid. On the basis of UHPLC-FT-ICR-MS analysis, systematic characterization of the chemical profile of Lanqin oral liquid was carried out, and a total of 441 compounds were identified or tentatively characterized including alkaloids, flavonoids, terpenoids, organic acids, phenylpropanoids, and other types. The results provide a reference for improving quality control, contribute to establishing higher quality standards, provide a scientific basis for further research on the pharmacodynamic material basis, and help illustrate the relationship between the complicated constituents and therapeutic effects of Lanqin oral liquid.
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