The Anp32 family of proteins containing leucine-rich repeats
The Anp32 family of proteins containing leucine-rich repeats
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DOI：
10.1080/14734220410019020
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发表时间：
2005-01-01
期刊：
影响因子：
3.5
通讯作者：
Radrizzani, M
中科院分区：
文献类型：
--
作者：
Matilla, A;Radrizzani, M
在这里，我们描述了Anp 32家族的特征，该家族由小脑富含亮氨酸的重复蛋白（Lanp）和小脑发育调节蛋白1（Cpd 1）代表。Anp 32家族由32个进化上保守的蛋白质组成，并且包括在富含亮氨酸重复序列（LRR）蛋白质的超家族内，其特征在于存在LRR的串联阵列，LRR是涉及蛋白质-蛋白质相互作用的介导的结构基序。我们描述了三种新的人类Anp 32蛋白，揭示了Anp 32家族成员的进化关系，提供了深入了解其生化和结构特性，并回顾了它们的大分子相互作用，底物特异性，组织分布/表达模式，以及生理和病理作用。最近的研究结果表明，在进化过程中，Anp 32家族成员在调节细胞信号传导和基因表达转导以调节细胞骨架的形态和动力学、细胞粘附、神经发育或小脑形态发生中的保守作用。
Herein we describe the characteristic features of the Anp32 family represented by the cerebellar leucine-rich repeat protein (Lanp) and the cerebellar developmental-regulated protein 1 (Cpd1). The Anp32 family consists of 32 evolutionarily conserved proteins and is included within the superfamily of leucine-rich repeat (LRR) proteins characterized by the presence of tandem arrays of a LRR, a structural motif implicated in the mediation of protein protein interactions. We describe three novel human Anp32 proteins, reveal the evolutionary relationships of the members of the Anp32 family, provide insights into their biochemical and structural properties, and review their macromolecular interactions, substrate specificities, tissue distribution/expression patterns, and physiological and pathological roles. Recent findings indicate a conserved role of members of the Anp32 family during evolution in the modulation of cell signalling and transduction of gene expression to regulate the morphology and dynamics of the cytoskeleton, cell adhesion, neural development or cerebellar morphogenesis.