Quantification of coronary artery lumen volume by digital angiography - In vivo validation
Quantification of coronary artery lumen volume by digital angiography - In vivo validation
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DOI：
10.1161/hc4401.098435
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发表时间：
2001-11-06
期刊：
影响因子：
37.8
通讯作者：
Zhou, YF
中科院分区：
文献类型：
--
作者：
Molloi, S;Kassab, GS;Zhou, YF
背景-在评估冠状动脉疾病时，冠状动脉管腔体积可能比常用的变量，如狭窄百分比或最小管腔直径，有几个潜在的优势。本研究的目的是验证视频密度技术对管腔体积的定量评估。方法和结果：9只体重20~55 kg的猪在左冠状动脉主干内注射对比剂(2mL/S，3s)后进行冠状动脉造影。使用相位匹配减影图像通过视频密度测量技术对局部管腔体积进行量化。体内的体积测量通过在生理压力下制作的冠状动脉树的聚合物模型来验证。测量的管腔体积(VC)与视频密度测量的局部管腔体积(V-Vd)之间的相关系数为：V-Vd=1.06V-C-0.01mL(r=0.99)。这些测量的均方根误差和系统误差分别为17%和-3%。结论-一种视频密度测量技术在体外和体内猪动物模型中都得到了验证。本研究结果证明了视频密度学技术在体内准确测量局部管腔体积的可行性和潜在的实用价值。这项研究有助于了解冠状动脉疾病的血管造影方法，并表明该技术可用于常规冠状动脉造影术中对弥漫性冠状动脉疾病的量化。
Background-Coronary artery lumen volume may potentially have several advantages over the commonly used variables, such as percent stenosis or minimal lumen diameter, in the assessment of coronary artery disease. The goal of this study is to validate a quantitative assessment of lumen volume using a video densitometry technique.Methods and Results-Coronary arteriography was performed in 9 swine (body weight 20 to 55 kg) after power injection of contrast material (2 mL/s for 3 seconds) into the left main coronary artery. Phase-matched subtracted images were used to quantify regional lumen volume by a video densitometry technique. The in vivo volume measurements were validated by a polymer cast of the coronary arterial tree made at physiological pressure. The measured cast volume (Vc) and video densitometric regional lumen volume (V-VD) were related by V-VD= 1.06 V-C-0.01 mL (r=0.99). The root mean square and systematic errors for these measurements were 17% and -3%, respectively.Conclusions-A video densitometry technique for quantification of coronary lumen volume was validated both in vitro and in vivo in a swine animal model. The present results demonstrated the feasibility and potential utility of the video densitometry technique for accurate measurement of regional lumen volume in vivo. This study contributes to the understanding of the angiographic methods used for the assessment of coronary artery disease and indicates that this technique can potentially be used for quantification of diffuse coronary artery disease during routine coronary arteriography.