Differential regional decline in dopamine receptor availability across adulthood: Linear and nonlinear effects of age.
Differential regional decline in dopamine receptor availability across adulthood: Linear and nonlinear effects of age.
复制标题
成年期多巴胺受体可用性的不同区域下降：年龄的线性和非线性影响。
DOI：
10.1002/hbm.24585
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发表时间：
2019
影响因子：
4.8
通讯作者：
Samanez-Larkin,GregoryR
中科院分区：
文献类型：
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作者：
Seaman,KendraL;Smith,ChristopherT;Juarez,EricJ;Dang,LinhC;Castrellon,JaimeJ;Burgess,LeahL;SanJuan,MDanica;Kundzicz,PaulM;Cowan,RonaldL;Zald,DavidH;Samanez-Larkin,GregoryR
基于神经心理测试结果和结构神经成像的成人大脑发育理论表明，皮质和皮质下亚区域与年龄相关的功能变化速度不同。然而，目前还不清楚这些趋势是否也延伸到老化的多巴胺系统。在这里，我们使用正电子发射计算机断层扫描成像和放射性示踪剂[18F]FallyPride在两个健康成人样本(组合N= 132)中检查了几个皮质和皮质下大脑区域D2样受体结合潜力估计的成年人年龄横截面差异。在考虑了总体放射性配基结合的地区差异后，受体结合潜力的估计百分比差异(线性效应)在大多数颞叶和额叶皮质区域最高(每十年约6-16%)，在海马旁回、前额叶皮质、梭状回、尾状回、壳核、丘脑和杏仁核中等(约3-5%)，在扣带下额叶皮质、腹侧纹状体、苍白球和海马区最弱(约0-2%)。有些区域表现出年龄的线性效应，而许多区域则表现出曲线效应，即结合潜力从青年到中年下降，然后相对稳定到老年。总体而言，这些数据表明，D2受体可获得性下降的速度和模式在地区上是不同的。然而，在现有的大脑发育理论中组织跨地区的差异是具有挑战性的，并且没有显示出在灰质体积、白质完整性或认知表现方面观察到的相同的地区变化模式。这种变化表明，现有的成人大脑发育理论可能需要修改，以更好地解释多巴胺能系统老化的空间动力学。
Theories of adult brain development, based on neuropsychological test results and structural neuroimaging, suggest differential rates of age‐related change in function across cortical and subcortical sub‐regions. However, it remains unclear if these trends also extend to the aging dopamine system. Here we examined cross‐sectional adult age differences in estimates of D2‐like receptor binding potential across several cortical and subcortical brain regions using PET imaging and the radiotracer [18F]Fallypride in two samples of healthy human adults (combinedN= 132). After accounting for regional differences in overall radioligand binding, estimated percent difference in receptor binding potential by decade (linear effects) were highest in most temporal and frontal cortical regions (~6–16% per decade), moderate in parahippocampal gyrus, pregenual frontal cortex, fusiform gyrus, caudate, putamen, thalamus, and amygdala (~3–5%), and weakest in subcallosal frontal cortex, ventral striatum, pallidum, and hippocampus (~0–2%). Some regions showed linear effects of age while many showed curvilinear effects such that binding potential declined from young adulthood to middle age and then was relatively stable until old age. Overall, these data indicate that the rate and pattern of decline in D2 receptor availability is regionally heterogeneous. However, the differences across regions were challenging to organize within existing theories of brain development and did not show the same pattern of regional change that has been observed in gray matter volume, white matter integrity, or cognitive performance. This variation suggests that existing theories of adult brain development may need to be modified to better account for the spatial dynamics of dopaminergic system aging.