Prospective study of serum vitamin E levels and esophageal and gastric cancers
Prospective study of serum vitamin E levels and esophageal and gastric cancers
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DOI：
10.1093/jnci/djg044
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发表时间：
2003-09-17
期刊：
影响因子：
--
通讯作者：
Mark, SD
中科院分区：
文献类型：
--
作者：
Taylor, PR;Qiao, YL;Mark, SD
普通人群试验是一项在中国临县进行的随机营养干预试验，接受硒、β-胡萝卜素和维生素 E 补充剂组合的参与者，其癌症死亡率在统计上显着低于未接受补充剂的参与者。在当前的研究中，我们使用病例队列设计来检查试验前血清维生素 E 水平与试验期间患食管癌和胃癌的风险之间的关联。我们测量了 1072 例食管鳞状细胞癌 (ESCC)、贲门癌 (GCC) 或胃非贲门癌 (GNCC) 患者以及 1053 名对照受试者的血清 α-和 γ-生育酚以及胆固醇水平。血清 α-生育酚最高与最低四分位数比较的相对风险，ESCC 为 0.63（95% CI = 0.44 至 0.91），GCC 为 0.84（95% CI = 0.55 至 1.26），GNCC 为 2.05（95% CI = 0.89 至 4.75）。血清γ-生育酚水平与这些癌症的发生率均无关。我们的研究结果为α-生育酚在上消化道癌症病因学中的作用提供了支持。
Participants in the General Population Trial, a randomized nutrition intervention trial in Linxian, China, who received a combination of selenium, beta-carotene, and vitamin E supplements, had statistically significantly lower cancer mortality rates than those who did not receive the supplements. In the current study, we used a case-cohort design to examine the association between pre-trial serum vitamin E levels and the risks of developing esophageal and gastric cancers during the trial. We measured serum alpha- and gamma-tocopherol and cholesterol levels in 1072 case patients with incident esophageal squamous cell carcinoma (ESCC), gastric cardia cancer (GCC), or gastric noncardia cancer (GNCC) and in 1053 control subjects. The relative risks for comparisons of the highest to the lowest quartiles of serum alpha-tocopherol were 0.63 (95% confidence interval [CI] = 0.44 to 0.91) for ESCC, 0.84 (95% CI = 0.55 to 1.26) for GCC, and 2.05 (95% CI = 0.89 to 4.75) for GNCC. Serum gamma-tocopherol level was not associated with the incidence of any of these cancers. Our findings provide support for the role of alpha-tocopherol in the etiology of upper gastrointestinal cancers.