Plasma alpha-synuclein levels are increased in patients with obstructive sleep apnea syndrome
Plasma alpha-synuclein levels are increased in patients with obstructive sleep apnea syndrome
复制标题
阻塞性睡眠呼吸暂停综合征患者血浆 α-突触核蛋白水平升高
DOI：
10.1002/acn3.756
复制
发表时间：
2019
影响因子：
5.3
通讯作者：
Bu Xian-Le
中科院分区：
文献类型：
--
作者：
Sun Hao-Lun;Sun Bin-Lu;Chen Dong-Wan;Chen Yang;Li Wei-Wei;Xu Man-Yu;Shen Ying-Ying;Xu Zhi-Qiang;Wang Yan-Jiang;Bu Xian-Le
阻塞性睡眠呼吸暂停综合征（OSAS）的特征是夜间间歇性低氧血症，可增加帕金森病的风险。本研究旨在探讨血浆α-突触核蛋白水平与OSAS患者缺氧之间的关系。方法我们招募了42名OSAS患者和46名年龄和性别匹配的单纯打鼾对照。根据临床症状和夜间多导睡眠图诊断OSAS。ELISA试剂盒检测血浆总α-synuclein和磷酸化α-synuclein水平。结果OSAS患者血浆总α-synuclein和磷酸化α-synuclein水平显著升高。上述两项指标均与呼吸暂停低通气指数和氧减饱和指数呈正相关，而与平均和最低氧合血红蛋白饱和度呈负相关。解释本研究提示慢性间歇性缺氧可使α-突触核蛋白水平升高，可能参与帕金森病的发病。
ObjectiveObstructive sleep apnea syndrome (OSAS) is characterized by nocturnal intermittent hypoxemia and can increase the risk of Parkinson's disease. This study aimed to investigate the association between plasmaα‐synuclein levels and hypoxia in the patients with OSAS.MethodsWe recruited 42 OSAS patients and 46 controls with simple snoring matched for age and gender. OSAS was diagnosed on the basis of the clinical symptoms as well as the nighttime polysomnography. Plasma totalα‐synuclein and phosphorylatedα‐synuclein levels were measured by ELISA kits.ResultsThe OSAS patients had significant higher levels of plasma totalα‐synuclein and phosphorylatedα‐synuclein levels. Both of the above indexes were positively correlated with the apnea–hypopnea index and the oxygen desaturation index, while they were negatively correlated with the mean and lowest oxyhemoglobin saturations.InterpretationThis study suggests that chronic intermittent hypoxia can increase theα‐synuclein levels, which may contribute to the pathogenesis of Parkinson's disease.