Health-related quality of life: Hepatocellular carcinoma, chronic liver disease, and the general population
Health-related quality of life: Hepatocellular carcinoma, chronic liver disease, and the general population
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DOI：
10.1007/s11136-006-9111-2
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发表时间：
2007-03-01
影响因子：
3.5
通讯作者：
Carr, Brian I.
中科院分区：
文献类型：
--
作者：
Steel, Jennifer L.;Chopra, Kapil;Carr, Brian I.
健康相关生活质量（HRQL）已成为检测慢性肝病（CLD）治疗疗效和CLD后果（包括肝细胞癌（HCC）和肝功能衰竭）的重要终点。然而，对这些患者人群进行的HRQL研究很少。本研究的目的是比较诊断为肝细胞癌的人诊断为CLD以及与一般人群（GP）的疾病特异性仪器测量HRQL。如果HRQL存在显著且有临床意义的差异，HRQL可用作CLD患者疾病进展的确证指标。272人参加了本研究。在这些参与者中，83人被诊断为HCC，51人患有CLD，138人来自GP。HCC或CLD样本中没有患者积极接受CLD或HCC的化疗治疗。对参与者进行社会人口统计学问卷调查和癌症治疗功能评估-肝胆（FACT-Hep）。研究结果表明，与CLD患者和普通人群相比，治疗前诊断为HCC的患者的总体HRQL较差，正如预期的那样。HRQL的差异具有统计学显著性和临床意义。分别被诊断为CLD和HCC的人报告了比普通人群更好的社会和家庭幸福感。此外，CLD患者报告了与一般人群样本相同的情感幸福感。HRQL分量表分数，除社会和家庭福祉，歧视组成员。
Health related quality of life (HRQL) has become an important endpoint in testing the efficacy of treatments for chronic liver disease (CLD) and the consequences of CLD which include hepatocellular carcinoma (HCC) and liver failure. However, a paucity of research on HRQL has been conducted with these patient populations. The aims of the present study were to compare persons diagnosed with HCC to persons diagnosed with CLD as well as with the general population (GP) on a disease-specific instrument measuring HRQL. If significant and clinically meaningful differences in HRQL exist, HRQL may be used as a corroborative indicator of disease progression in patients with CLD. Two hundred and seventy-two people participated in the present study. Of these participants, 83 were diagnosed with HCC, 51 with CLD, and 138 were from the GP. None of the patients in the HCC or CLD samples were actively receiving chemotherapeutic treatments for the CLD or HCC. A sociodemographic questionnaire and the Functional Assessment of Cancer Therapy-Hepatobiliary (FACT-Hep) was administered to participants. The results of the study suggested that people diagnosed with HCC, prior to treatment, had a poorer overall HRQL when compared to those persons with CLD and the general population, as expected. The differences in HRQL were statistically significant as well as clinically meaningful. People diagnosed with CLD and HCC respectively, reported better social and family well-being than the general population. Furthermore, people with CLD reported equivalent emotional well-being as the general population sample. HRQL subscale scores, with the exception of social and family well-being, discriminated group membership.