Corticotropin-releasing factor directly mediates colonic responses to stress.
Corticotropin-releasing factor directly mediates colonic responses to stress.
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DOI：
10.1152/ajpgi.1987.253.4.g582
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发表时间：
1987-10
期刊：
影响因子：
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通讯作者：
C. L. Williams;J. M. Peterson;R. Villar;T. Burks
中科院分区：
文献类型：
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作者：
C. L. Williams;J. M. Peterson;R. Villar;T. Burks
一种新的大鼠应激模型产生的肠道功能变化与人类应激相关的肠道功能障碍模式相似：小肠运输受到抑制，大肠运输受到刺激，粪便排泄受到刺激。为了评估促肾上腺皮质激素释放因子（CRF）在介导应激对肠道影响中的作用，我们研究了外源性CRF对大鼠小肠和大肠传输的作用，并表征了药物阻断CRF受体对应激的影响诱导的肠道功能障碍。给予外源性CRF（0.3-10.0 μ g iv或icv）导致剂量相关的胃排空抑制、小肠转运抑制、结肠转运刺激和粪便排泄刺激。外源性CRF的作用模拟应激对胃肠道运动活动的影响。给药α-螺旋CRF-（9-41）（50微克静脉或icv），CRF拮抗剂，防止应激诱导的大肠转运增加和相关的粪便排泄增加。这些数据表明，内源性CRF可能介导应激诱导的结肠功能的变化。
A new stress model in rats produced changes in intestinal function that resemble patterns of intestinal dysfunction associated with stress in humans: small intestinal transit was inhibited, large intestinal transit was stimulated, and fecal excretion was stimulated. To evaluate the role of corticotropin-releasing factor (CRF) in mediating the effects of stress on the intestine, we studied the actions of exogenous CRF on small and large intestinal transit in the rat and characterized the effects of pharmacological blockade of CRF receptors on stress-induced intestinal dysfunction. Administration of exogenous CRF (0.3-10.0 micrograms iv or icv) resulted in dose-related inhibition of gastric emptying, inhibition of small intestinal transit, stimulation of colonic transit, and stimulation of fecal excretion. The actions of exogenous CRF mimicked the effects of stress on the motor activity of the gastrointestinal tract. Administration of alpha-helical CRF-(9-41) (50 micrograms iv or icv), an antagonist of CRF, prevented the stress-induced increase in large intestinal transit and the associated increase in fecal excretion. These data suggest that endogenous CRF may mediate stress-induced changes in colonic function.