Association Between Dietary Salt Intake and Open Angle Glaucoma in the Thessaloniki Eye Study.
Association Between Dietary Salt Intake and Open Angle Glaucoma in the Thessaloniki Eye Study.
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DOI：
10.1097/ijg.0000000000002044
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发表时间：
2022-07-01
影响因子：
2
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中科院分区：
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在塞萨洛尼基眼科研究（TES）人群中，通过抗高血压药物的使用来检查饮食中盐摄入量与青光眼之间的关系。研究人群包括TES发病阶段的参与者。通过自我报告评估膳食盐摄入频率。结果包括任何开角型青光眼（OAG）、原发性开角型青光眼（POAG）和假性剥脱（PEX）的患病率。协变量包括人口统计学、心血管疾病、偏头痛、糖尿病、类固醇使用、吸烟、白内障手术史、中央角膜厚度、眼内压、血压和抗高血压药物使用。Logistic回归分析用于检查盐摄入频率与青光眼之间的关系，控制协变量，并按抗高血压药物的使用分层。该研究包括1，076名80.5±4.4岁的参与者，其中518名为女性。89/1，076（8.3%）例受试者患有任何OAG，46/789（5.8%）例患有POAG，287/1，030（27.9%）例患有PEX。在使用抗高血压药物的参与者中，频繁摄入盐与从不摄入盐与任何OAG风险增加相关（校正比值比[aOR]=2.65，95%置信区间[CI]=1.12，6.28; n=784）和POAG（aOR=3.59，95% CI=1.16，11.11; n=578）总体，以及舒张压<90 mmHg的参与者（aOR=2.42，95%CI =1.00，5.84; n=735）。在盐摄入量和PEX之间，或在未使用抗高血压药物的参与者中，没有统计学显著的校正相关性。在评估OAG患病率和发病率阶段的TES参与者中，频繁的盐摄入可能与服用抗高血压药物的OAG增加相关。高血压患者盐摄入量与青光眼的关系还需进一步研究。在塞萨洛尼基眼科研究发病阶段人群中，频繁的饮食盐摄入可能与抗高血压药物使用者开角型青光眼风险增加相关。
To examine the association between dietary salt intake and glaucoma by antihypertensive use in the Thessaloniki Eye Study (TES) population. The study population included TES incidence phase participants. Dietary salt intake frequency was assessed by self-report. Outcomes included prevalence of any open angle glaucoma (OAG), primary open angle glaucoma (POAG), and pseudoexfoliation (PEX). Covariates included demographics, cardiovascular disease, migraines, diabetes, steroid use, smoking, history of cataract surgery, central corneal thickness, intraocular pressure, blood pressure, and antihypertensive use. Logistic regression was used to examine associations between frequency of salt intake and glaucoma, controlling for covariates and stratified by antihypertensive use. The study included 1,076 participants 80.5±4.4 years old, of whom 518 were female. There were 89/1,076 (8.3%) participants with any OAG, 46/789 (5.8%) with POAG, and 287/1,030 (27.9%) with PEX. In participants with antihypertensive use, frequent versus never salt intake was associated with increased risk of any OAG (adjusted odds ratio [aOR]=2.65, 95% confidence interval [CI]=1.12, 6.28; n=784) and POAG (aOR=3.59, 95% CI=1.16, 11.11; n=578) overall, and additionally in participants with diastolic blood pressure <90mmHg (aOR=2.42, 95% CI=1.00, 5.84; n=735) for OAG. There were no statistically significant adjusted associations between salt intake and PEX, or in participants without antihypertensive use. In TES participants assessed for OAG in the prevalence and incidence phases, frequent salt intake may be associated with increased OAG in those who take antihypertensive medication. Further investigation is needed of salt intake and glaucoma in hypertensive individuals. In the Thessaloniki Eye Study incidence phase population, frequent dietary salt intake was potentially associated with increased risk of open-angle glaucoma in antihypertensive users.