Histologic grade as prognostic indicator for mucoepidermoid carcinoma: A population-level analysis of 2400 patients
Histologic grade as prognostic indicator for mucoepidermoid carcinoma: A population-level analysis of 2400 patients
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DOI：
10.1002/hed.23256
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发表时间：
2014-02-01
影响因子：
2.9
通讯作者：
Judson, Benjamin L.
中科院分区：
文献类型：
--
作者：
Chen, Michelle M.;Roman, Sanziana A.;Judson, Benjamin L.
背景粘液表皮样癌（MEC）是一种罕见的恶性肿瘤。据我们所知，这是调查腮腺 MEC 疾病特异性生存 (DSS) 的最大研究，也是第一个关于淋巴结转移分布的人群水平研究。方法在监测、流行病学和最终结果 (SEER) 数据库（1988-2009）中确定了腮腺 MEC 患者。结果我们确定了 2400 名 MEC 患者：522 名低 等级、中级1137、高级741。低级、中级和高级 MEC 的五年 DSS 率分别为 98.8%、97.4% 和 67.0% (p < .001)。负面预后因素包括高级别、患者年龄增加、肿瘤大小、实质外扩展、淋巴结转移和远处转移。高级别 MEC 比低级别 (3.3%) 和中级别 MEC (8.1%；p < .001) 更有可能出现 I 至 III 级淋巴结转移 (34.0%)。 结论 级别影响预后和淋巴结转移的分布。结果表明，管理指南应根据年级而有所不同。 (c) 2013 年 Wiley 期刊公司 Head Neck 36：158-163，2014 年
BackgroundMucoepidermoid carcinoma (MEC) is an uncommon malignancy. To the best of our knowledge, this is the largest study investigating disease-specific survival (DSS) of parotid MEC and the first population-level study of the distribution of nodal metastases.MethodsPatients with MEC of the parotid gland were identified in the Surveillance, Epidemiology, and End Results (SEER) database (1988-2009).ResultsWe identified 2400 patients with MEC: 522 low grade, 1137 intermediate grade, and 741 high grade. Five-year DSS rates for low-grade, intermediate-grade, and high-grade MEC were 98.8%, 97.4%, and 67.0%, respectively (p < .001). Negative prognostic factors included high grade, increasing patient age, and tumor size, extraparenchymal extension, nodal metastases, and distant metastases. High-grade MEC was more likely to have lymph node metastases in levels I to III (34.0%) than low-grade (3.3%) and intermediate-grade MEC (8.1%; p < .001).ConclusionGrade influences the prognosis and distribution of nodal metastases. Results indicate that management guidelines should vary based on grade. (c) 2013 Wiley Periodicals, Inc. Head Neck 36: 158-163, 2014