STAT3 Expression in Host Myeloid Cells Controls Graft-versus-Host Disease Severity.
STAT3 Expression in Host Myeloid Cells Controls Graft-versus-Host Disease Severity.
复制标题
DOI：
10.1016/j.bbmt.2017.06.018
复制
发表时间：
2017-10
期刊：
影响因子：
--
通讯作者：
Reddy P
中科院分区：
文献类型：
--
作者：
Nieves EC;Toubai T;Peltier DC;Oravecz-Wilson K;Liu C;Tamaki H;Sun Y;Reddy P
专业抗原呈递细胞（APCs）是急性移植物抗宿主病（GVHD）的重要调节因子。尽管树突状细胞（dc）是最有效的APC亚群，但其他髓系细胞，特别是巨噬细胞（MFs）和中性粒细胞最近被证明在GVHD的严重程度中发挥作用。然而，决定髓系细胞在GVHD中功能的关键分子机制尚不清楚。STAT3 （Signal transducer and activator of transcription 3）是在免疫调节中起重要作用的主转录因子。但其在MF生物学和急性GVHD中的作用尚不清楚。为了确定髓系细胞特异性表达STAT3对急性GVHD严重程度的作用，我们利用髓系细胞特异性表达STAT3缺陷的LysM-Cre/STAT3fl/−动物作为急性GVHD实验模型的受体和供体。我们发现来自宿主而非供体的骨髓细胞中STAT3的表达降低，炎症增加，供体T细胞活化和GVHD加重。我们的数据表明，宿主骨髓细胞(如MFs)中的STAT3可以抑制急性GVHD。
Professional antigen presenting cell (APCs) are important modulators of acute graft-versus-host disease (GVHD). Although dendritic cells (DCs) are most potent APC subset, other myeloid cells, especially macrophages (MFs) and neutrophils have recently been shown to play a role in the severity of GVHD. However, the critical molecular mechanisms that determine the functions of myeloid cells in GVHD are unclear. Signal transducer and activator of transcription 3 (STAT3) is a master transcription factor that plays a crucial role in regulating immunity. But its role in MF biology and in acute GVHD remains unknown. To determine the role of myeloid cell specific expression of STAT3 on the severity of acute GVHD, we utilized myeloid cell specific STAT3 deficient LysM-Cre/STAT3fl/− animals as recipients and donors in well-characterized experimental models of acute GVHD. We found that reduced expression of STAT3 in myeloid cells from the hosts, but not the donors, increased inflammation, donor T cell activation and exacerbated GVHD. Our data demonstrate that STAT3 in host myeloid cells, such as MFs, dampens acute GVHD.
登录
查看更多内容
DOI：
10.1016/s1470-2045(13)70512-6
发表时间：
2014-01
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Choi SW;Braun T;Chang L;Ferrara JL;Pawarode A;Magenau JM;Hou G;Beumer JH;Levine JE;Goldstein S;Couriel DR;Stockerl-Goldstein K;Krijanovski OI;Kitko C;Yanik GA;Lehmann MH;Tawara I;Sun Y;Paczesny S;Mapara MY;Dinarello CA;DiPersio JF;Reddy P
通讯作者：
Reddy P
DOI：
10.1084/jem.20081633
发表时间：
2009-02-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Haniffa M;Ginhoux F;Wang XN;Bigley V;Abel M;Dimmick I;Bullock S;Grisotto M;Booth T;Taub P;Hilkens C;Merad M;Collin M
通讯作者：
Collin M
影响因子：
20.3
作者：
Das, Rupali;Chen, Xiao;Drobyski, William R.
通讯作者：
Drobyski, William R.
影响因子：
20.3
作者：
Capitini, Christian M.;Nasholm, Nicole M.;Fry, Terry J.
通讯作者：
Fry, Terry J.
DOI：
10.1073/pnas.0600666103
发表时间：
2006-05-23
影响因子：
11.1
作者：
Chen, Zhi;Laurence, Arian;O'Shea, John J.
通讯作者：
O'Shea, John J.