Detection of Magnetic Nanoparticles Using the Second-Harmonic Signal
Detection of Magnetic Nanoparticles Using the Second-Harmonic Signal
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DOI：
10.1109/tmag.2011.2157805
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发表时间：
2011-09
影响因子：
2.1
通讯作者：
T. Yoshida;K. Ogawa;T. Tsubaki;N. Othman;K. Enpuku
中科院分区：
文献类型：
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作者：
T. Yoshida;K. Ogawa;T. Tsubaki;N. Othman;K. Enpuku
我们开发了一个检测系统的磁性纳米粒子（MNP）使用的二次谐波信号。通过测量MNP的二次谐波信号，与测量基波信号的情况相比，我们可以显着降低激励场的干扰。首先，我们探讨了当施加直流偏置场和交流场时，来自MNP的谐波信号的性质。我们得到了二次谐波达到峰值时的直流场和交流场之间的关系。在这些结果的基础上，我们开发了一个检测系统的MNP使用一个简单的感应拾波线圈梯度计。梯度仪的灵敏度为7668 V/T，在38.6 kHz的信号频率下，最小可探测场为10 pT。我们可以检测到100 μg的MNP位于拾取线圈下30 mm的距离。MNP的位置也可以从信号场的等高线图中检测到。这种简单的检测系统将用于前哨淋巴结活检等医疗应用。
We developed a detection system for magnetic nanoparticles (MNPs) using the second-harmonic signal. By measuring the second-harmonic signal from MNPs, we can significantly reduce the interference of the excitation field, compared to the case of measuring the fundamental signal. First, we explored the properties of harmonic signals from MNPs when both a DC bias field and an AC field were applied. We obtained the relationship between the DC and AC fields under which the second harmonic reached its peaks. On the basis of these results, we developed a detection system for MNPs using a simple inductive pickup coil gradiometer. The sensitivity of the gradiometer was 7668 V/T and the minimum detectable field was 10 pT at a signal frequency of 38.6 kHz. We could detect 100 μg of MNPs located under the pickup coil at a distance of 30 mm. The position of MNPs was also detected from the contour map of the signal field. This simple detection system will be used in medical applications such as sentinel lymph node biopsy.