The D-2 dopamine receptor gene as a determinant of reward deficiency syndrome
The D-2 dopamine receptor gene as a determinant of reward deficiency syndrome
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DOI：
10.1177/014107689608900711
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发表时间：
1996-07-01
影响因子：
17.3
通讯作者：
Comings, DE
中科院分区：
文献类型：
--
作者：
Blum, K;Sheridan, PJ;Comings, DE
多巴胺能系统，特别是多巴胺D-2受体，与大脑中的奖赏机制有着深刻的联系。D-2多巴胺受体的功能障碍导致异常的物质寻求行为（酒精、药物、烟草和食物）和其他相关行为（病理性赌博、图雷特综合征和注意力缺陷多动障碍）。我们提出，D-2多巴胺受体基因的变体是“奖赏缺乏综合征”的重要共同遗传决定因素。
The dopaminergic system, and in particular the dopamine D-2 receptor, has been profoundly implicated in reward mechanisms in the brain, Dysfunction of the D-2 dopamine receptors leads to aberrant substance seeking behaviour (alcohol, drug, tobacco, and food) and other related behaviours (pathological gambling, Tourette's syndrome, and attention deficit hyperactivity disorder). We propose that variants of the D-2 dopamine receptor gene are important common genetic determinants of the 'reward deficiency syndrome'.