Effect of deflazacort on cardiac and sternocleidomastoid muscles in Duchenne muscular dystrophy: A magnetic resonance imaging study
Effect of deflazacort on cardiac and sternocleidomastoid muscles in Duchenne muscular dystrophy: A magnetic resonance imaging study
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DOI：
10.1016/j.ejpn.2008.02.006
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发表时间：
2009-01-01
影响因子：
3.1
通讯作者：
Cokkinos, Dennis V.
中科院分区：
文献类型：
--
作者：
Mavrogeni, Sophie;Papavasiliou, Antigoni;Cokkinos, Dennis V.
目的：通过磁共振成像（MRI）测量T2舒张时间和左心室收缩功能来评估接受地夫可特治疗的杜氏肌营养不良症（DMD）患者心脏和胸锁乳突肌的受累情况，并与未经治疗的DMD患者进行比较。 对象：17名接受地夫可特治疗的DMD患者（年龄17-22岁） 地夫可特治疗至少 7 年，17 名患有 DMD 的年轻（12-15 岁）男孩未接受类固醇治疗。所有患者均无心脏或呼吸道症状，心电图和动态心电图检查正常。方法：采用磁共振成像（MRI）评估两组DMD患者心肌（H）、左胸锁乳突肌（SCM-L）和右胸锁乳突肌（SCM-R）的T2舒张时间以及左心室收缩功能。使用 16 个 TE（10-85 毫秒）和至少 2000 毫秒的 TR 计算心肌和胸锁乳突肌 T2 松弛时间，并创建 T2 图。结果：地夫可特 DMD 具有更高的心脏和双侧胸锁乳突肌 T2 松弛时间值（T2H 中位值（范围）：47 (41-48) vs. 33 (31-37)） ms，p < 0.001，T2 SCM-L 中值（范围）：35 (30-37) 与 23 (20-26) ms，p < 0.001，T2 SCM-R 中值（范围）：35 (32-37) 与 23 (20-27)ms，p
Objective: To evaluate the involvement of cardiac and sternocleidomastoid muscles by magnetic resonance imaging (MRI) measurement of T2 relaxation time and the left ventricular systolic function in patients with Duchenne muscular dystrophy (DMD) on treatment with deflazacort and compare them with DMD patients without treatment.Subjects: Seventeen patients with DMD (aged 17-22 years) on treatment with deflazacort for at least 7 years and 17 boys with DMD of younger age (12-15 years) without steroid treatment. All patients were free of cardiac or respiratory symptoms and had normal ECG and Holter monitor examination.Methods: T2 relaxation time of the myocardium (H), left (SCM-L) and right sternocleidomastoid (SCM-R) muscles and left ventricular systolic function were evaluated by magnetic resonance imaging (MRI) in two groups of DMD patients. Myocardial and sternocleidomastoid muscles T2 relaxation time was calculated using 16 TEs (10-85 msec) and TR at least 2000 ms and T2 maps were created.Results: DMD on deflazacort had higher T2 relaxation time values of the heart and of both sternocleidomastoid muscles (T2H median (range): 47 (41-48) vs. 33 (31-37) ms, p < 0.001, T2 SCM-L median (range): 35 (30-37) vs. 23 (20-26) ms, p < 0.001, T2 SCM-R median (range): 35 (32-37) vs. 23 (20-27)ms, p