Endometriosis: Epidemiology, Diagnosis and Clinical Management.
Endometriosis: Epidemiology, Diagnosis and Clinical Management.
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DOI：
10.1007/s13669-017-0187-1
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发表时间：
2017-03
影响因子：
0.5
通讯作者：
Terry KL
中科院分区：
文献类型：
--
作者：
Parasar P;Ozcan P;Terry KL
子宫内膜异位症是一种青少年和育龄妇女的疾病，其特征是子宫腔外的子宫内膜组织，通常与慢性盆腔疼痛和不孕症有关。在这里，我们回顾了子宫内膜异位症的流行病学，以及可能用于检测的生物标志物，目的是强调危险因素，可以与生物标志物结合使用，以早期识别和治疗子宫内膜异位症妇女。月经初潮早、月经较短、身高较高与子宫内膜异位症的风险较高相关，而产次、较高的体重指数(BMI)和吸烟与风险较低相关。子宫内膜异位症通常表现为不孕不育或持续的盆腔疼痛，尽管使用了止痛药和周期口服避孕药。尽管有一系列的症状，但由于缺乏非侵入性的、明确的和一致的诊断子宫内膜异位症的生物标志物，子宫内膜异位症的诊断往往被延误。激素疗法和镇痛剂用于治疗症状性子宫内膜异位症。然而，这些治疗方法的疗效是有限的，因为子宫内膜异位症经常复发。在这篇综述中，我们描述了潜在的诊断生物标志物和危险因素，它们可以作为早期无创性的体外工具来识别子宫内膜异位症，以最大限度地减少诊断延迟，改善患者的生殖健康。
Endometriosis is a disease of adolescents and reproductive-aged women characterized by the presence of endometrial tissue outside the uterine cavity and commonly associated with chronic pelvic pain and infertility. Here we review the epidemiology of endometriosis as well as potential biomarkers for detection and with the goal of highlighting risk factors that could be used in combination with biomarkers to identify and treat women with endometriosis earlier.. Early age at menarche, shorter menstrual length, and taller height are associated with a higher risk of endometriosis while parity, higher body mass index (BMI) and smoking are associated with decreased risk. Endometriosis often presents as infertility or continued pelvic pain despite treatment with analgesics and cyclic oral contraceptive pills. Despite a range of symptoms, diagnosis of endometriosis is often delayed due to lack of non-invasive, definitive and consistent biomarkers for diagnosis of endometriosis. Hormone therapy and analgesics are used for treatment of symptomatic endometriosis. However, the efficacy of these treatments are limited as endometriosis often recurs. In this review, we describe potential diagnostic biomarkers and risk factors that may be used as early non-invasive in vitro tools for identification of endometriosis to minimize diagnostic delay and improve reproductive health of patients.