Comparative immunopeptidomics of humans and their pathogens
Comparative immunopeptidomics of humans and their pathogens
复制标题
DOI：
10.1073/pnas.0404740101
复制
发表时间：
2004-09-07
影响因子：
11.1
通讯作者：
Hoffman, SL
中科院分区：
文献类型：
--
作者：
Istrail, S;Florea, L;Hoffman, SL
主要组织相容性复合物I类分子将8-10个残基的肽呈递给CD 8 + T细胞。我们使用了19个预测的蛋白质组，通过预测免疫肽组，即，存在于蛋白质组中的I类结合肽的集合。我们发现，I类肽结合特异性（i）对免疫肽组的进化几乎没有影响，（ii）除了NH 2-末端前导序列中疏水残基的浓度外，不利用蛋白质中氨基酸分布的偏倚。
Major histocompatibility complex class I molecules present peptides of 8-10 residues to CD8+ T cells. We used 19 predicted proteomes to determine the influence of CD8+ T cell immune surveillance on protein evolution in humans and microbial pathogens by predicting immunopeptidomes, i.e., sets of class I binding peptides present in proteomes. We find that class I pepticle binding specificities (i) have had little, if any, influence on the evolution of immunopeptidomes and (ii) do not take advantage of biases in amino acid distribution in proteins other than the concentration of hydrophobic residues in NH2-terminal leader sequences.